PGS Publication: PGP000437

Publication Information (EuropePMC)
Title Melanoma risk prediction based on a polygenic risk score and clinical risk factors.
PubMed ID 37096571(Europe PMC)
doi 10.1097/cmr.0000000000000896
Publication Date April 24, 2023
Journal Melanoma Res
Author(s) Wong CK, Dite GS, Spaeth E, Murphy NM, Allman R.
Released in PGS Catalog: Oct. 17, 2023

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS003430
(GTG_Melanoma)
 PGP000437 |
Wong CK et al. Melanoma Res (2023)
 Melanoma melanoma 68
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003430/ScoringFiles/PGS003430.txt.gz - Check Terms/Licenses

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM017104 PGS003430
(GTG_Melanoma)
 PSS010127|
European Ancestry|
109,597 individuals
 PGP000437 |
Wong CK et al. Melanoma Res (2023)
 Reported Trait: Melanoma — AUROC: 0.634 [0.618, 0.661] — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS010127 — —
[
  • 640 cases
  • , 108,957 controls
]
,
46.0 % Male samples
 Range = [40, 69] years European — UKB —