PGS Publication: PGP000465

Publication Information (EuropePMC)
Title Genome-wide Association Study Shows That Executive Functioning Is Influenced by GABAergic Processes and Is a Neurocognitive Genetic Correlate of Psychiatric Disorders.
PubMed ID 36150907(Europe PMC)
doi 10.1016/j.biopsych.2022.06.034
Publication Date July 14, 2022
Journal Biol Psychiatry
Author(s) Hatoum AS, Morrison CL, Mitchell EC, Lam M, Benca-Bachman CE, Reineberg AE, Palmer RHC, Evans LM, Keller MC, Friedman NP.
Released in PGS Catalog: April 28, 2023

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS003724
(IQ)
 PGP000465 |
Hatoum AS et al. Biol Psychiatry (2022)
 Intelligence quotient intelligence 6,683,248
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003724/ScoringFiles/PGS003724.txt.gz
PGS003723
(cEF)
 PGP000465 |
Hatoum AS et al. Biol Psychiatry (2022)
 Common executive function executive function measurement 6,683,248
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003723/ScoringFiles/PGS003723.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM018417 PGS003723
(cEF)
 PSS010959|
European Ancestry|
916 individuals
 PGP000465 |
Hatoum AS et al. Biol Psychiatry (2022)
 Reported Trait: Common Executive Function β: 0.171 — R²: 0.136 PCs1-10, genotyping batch, IQ PGS cEF and IQ were genetically correlated (0.61) so were used as covariates in the PGS prediction model.
PPM018418 PGS003724
(IQ)
 PSS010959|
European Ancestry|
916 individuals
 PGP000465 |
Hatoum AS et al. Biol Psychiatry (2022)
 Reported Trait: Intelligence quotient β: 0.149 — R²: 0.121 PCs1-10, genotyping batch, cEF PGS cEF and IQ were genetically correlated (0.61) so were used as covariates in the PGS prediction model.

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS010959 — — 916 individuals — European — COL_Twin —