PGS Publication: PGP000483

Publication Information (EuropePMC)
Title Integrating polygenic and clinical risks to improve stroke risk stratification in prospective Chinese cohorts.
PubMed ID 36881318(Europe PMC)
doi 10.1007/s11427-022-2280-3
Publication Date March 3, 2023
Journal Sci China Life Sci
Author(s) Cui Q, Liu F, Li J, Niu X, Liu Z, Shen C, Hu D, Huang K, Chen S, Cao J, Liu X, Yu L, Lu F, Wu X, Zhao L, Huang J, Li Y, Hu Z, Shen H, Gu D, Lu X.
Released in PGS Catalog: Aug. 4, 2023

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Additional Diverse Ancestries
Not Reported

External PGS Evaluated By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS002259
(metaPRS_Stroke)
 PGP000285 |
Lu X et al. Neurology (2021)
 Stroke stroke 534
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002259/ScoringFiles/PGS002259.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM018556 PGS002259
(metaPRS_Stroke)
 PSS011021|
East Asian Ancestry|
41,006 individuals
 PGP000483 |
Cui Q et al. Sci China Life Sci (2023)
|Ext.		 Reported Trait: Incident stroke — — Hazard ratio (HR, high vs low tertile): 3.01 [2.03, 4.45] Sex, cohort Age as the underlying time scale
PPM018557 PGS002259
(metaPRS_Stroke)
 PSS011021|
East Asian Ancestry|
41,006 individuals
 PGP000483 |
Cui Q et al. Sci China Life Sci (2023)
|Ext.		 Reported Trait: Incident stroke with high clinical risk — — Hazard ratio (HR, high vs low tertile): 2.12 [1.38, 3.27] Sex, cohort Age as the underlying time scale

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011021 — Mean = 9.0 years 41,006 individuals,
43.1 % Male samples
 Mean = 51.9 years
Sd = 10.6 years		 East Asian
(Chinese)		 — InterASIA China MUCA 1998, CIMIC