PGS Publication: PGP000496

Publication Information (EuropePMC)
Title Genome-wide association study of obstructive sleep apnoea in the Million Veteran Program uncovers genetic heterogeneity by sex.
PubMed ID 36989840(Europe PMC)
doi 10.1016/j.ebiom.2023.104536
Publication Date March 28, 2023
Journal EBioMedicine
Author(s) Sofer T, Kurniansyah N, Murray M, Ho YL, Abner E, Esko T, Estonian Biobank Research Team, Huffman JE, Cho K, Wilson PWF, Gottlieb DJ, VA Million Veteran Program.
Released in PGS Catalog: Sept. 1, 2023

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS003857
(GRS18_BMIunadj)
 PGP000496 |
Sofer T et al. EBioMedicine (2023)
 Obstructive sleep apnea obstructive sleep apnea 18
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003857/ScoringFiles/PGS003857.txt.gz
PGS003858
(GRS6_BMIadj)
 PGP000496 |
Sofer T et al. EBioMedicine (2023)
 Obstructive sleep apnea (BMI adjusted) obstructive sleep apnea 6
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003858/ScoringFiles/PGS003858.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM018710 PGS003857
(GRS18_BMIunadj)
 PSS011076|
Multi-ancestry (including European)|
40,193 individuals
 PGP000496 |
Sofer T et al. EBioMedicine (2023)
 Reported Trait: BMI adjusted obstructive sleep apnea β: 0.014 (0.017) AUROC: 0.77 [0.75, 0.78] — BMI, age, sex, genetic batch, PCs 1-10 —
PPM018711 PGS003858
(GRS6_BMIadj)
 PSS011076|
Multi-ancestry (including European)|
40,193 individuals
 PGP000496 |
Sofer T et al. EBioMedicine (2023)
 Reported Trait: BMI unadjusted obstructive sleep apnea β: 0.048 (0.015) AUROC: 0.62 [0.61, 0.64] — age, sex, genetic batch, PCs 1-10 —
PPM018712 PGS003858
(GRS6_BMIadj)
 PSS011076|
Multi-ancestry (including European)|
40,193 individuals
 PGP000496 |
Sofer T et al. EBioMedicine (2023)
 Reported Trait: BMI adjusted obstructive sleep apnea β: 0.066 (0.017) AUROC: 0.77 [0.76, 0.79] — BMI, age, sex, genetic batch, PCs 1-10 —
PPM018709 PGS003857
(GRS18_BMIunadj)
 PSS011076|
Multi-ancestry (including European)|
40,193 individuals
 PGP000496 |
Sofer T et al. EBioMedicine (2023)
 Reported Trait: BMI unadjusted obstructive sleep apnea β: 0.082 (0.016) AUROC: 0.66 [0.64, 0.67] — age, sex, genetic batch, PCs 1-10 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011076 — — 2,023 individuals,
37.4 % Male samples
 Mean = 53.16 years
Sd = 16.23 years		 African unspecified — MGBB —
PSS011076 — — 932 individuals,
41.8 % Male samples
 Mean = 47.0 years
Sd = 15.67 years		 Asian unspecified — MGBB —
PSS011076 — — 34,764 individuals,
46.7 % Male samples
 Mean = 60.62 years
Sd = 16.83 years		 European — MGBB —
PSS011076 — — 1,182 individuals,
31.3 % Male samples
 Mean = 52.29 years
Sd = 16.56 years		 Hispanic or Latin American — MGBB —
PSS011076 — — 1,292 individuals,
46.8 % Male samples
 Mean = 52.08 years
Sd = 18.42 years		 Not reported — MGBB —