PGS Catalog - Clark R, EBioMedicine (2023) (Publication)

Polygenic Score ID & Name	PGS Publication ID (PGP)	Reported Trait	Mapped Trait(s) (Ontology)	Number of Variants	Ancestry distribution GWAS Dev Eval	Scoring File (FTP Link)
PGS003860 (PGS_RE)	PGP000498 \| Clark R et al. EBioMedicine (2023)	Refractive error	refractive error measurement	767,867		https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003860/ScoringFiles/PGS003860.txt.gz - Check Terms/Licenses

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID (PPM)	Evaluated Score	PGS Sample Set ID (PSS)	Performance Source	Trait	PGS Effect Sizes (per SD change)	Classification Metrics	Other Metrics	Covariates Included in the Model	PGS Performance: Other Relevant Information
PPM018722	PGS003860 (PGS_RE)	PSS011080\| European Ancestry\| 6,000 individuals	PGP000498 \| Clark R et al. EBioMedicine (2023)	Reported Trait: Low myopia	—	AUROC: 0.728 [0.715, 0.741]	—	—	—
PPM018736	PGS003860 (PGS_RE)	PSS011083\| South Asian Ancestry\| 4,641 individuals	PGP000498 \| Clark R et al. EBioMedicine (2023)	Reported Trait: High myopia (HM6)	—	AUROC: 0.706 [0.668, 0.743]	—	—	—
PPM018723	PGS003860 (PGS_RE)	PSS011078\| African Ancestry\| 4,089 individuals	PGP000498 \| Clark R et al. EBioMedicine (2023)	Reported Trait: Low myopia	—	AUROC: 0.582 [0.563, 0.601]	—	—	—
PPM018725	PGS003860 (PGS_RE)	PSS011079\| East Asian Ancestry\| 978 individuals	PGP000498 \| Clark R et al. EBioMedicine (2023)	Reported Trait: Low myopia	—	AUROC: 0.653 [0.619, 0.687]	—	—	—
PPM018726	PGS003860 (PGS_RE)	PSS011080\| European Ancestry\| 6,000 individuals	PGP000498 \| Clark R et al. EBioMedicine (2023)	Reported Trait: Moderate myopia	—	AUROC: 0.754 [0.738, 0.77]	—	—	—
PPM018727	PGS003860 (PGS_RE)	PSS011078\| African Ancestry\| 4,089 individuals	PGP000498 \| Clark R et al. EBioMedicine (2023)	Reported Trait: Moderate myopia	—	AUROC: 0.596 [0.566, 0.626]	—	—	—
PPM018728	PGS003860 (PGS_RE)	PSS011083\| South Asian Ancestry\| 4,641 individuals	PGP000498 \| Clark R et al. EBioMedicine (2023)	Reported Trait: Moderate myopia	—	AUROC: 0.686 [0.664, 0.708]	—	—	—
PPM018737	PGS003860 (PGS_RE)	PSS011079\| East Asian Ancestry\| 978 individuals	PGP000498 \| Clark R et al. EBioMedicine (2023)	Reported Trait: High myopia (HM6)	—	AUROC: 0.672 [0.619, 0.724]	—	—	—
PPM018739	PGS003860 (PGS_RE)	PSS011081\| European Ancestry\| 1,649 individuals	PGP000498 \| Clark R et al. EBioMedicine (2023)	Reported Trait: Refractive error	—	—	R²: 0.141 [0.112, 0.171]	—	—
PPM018729	PGS003860 (PGS_RE)	PSS011079\| East Asian Ancestry\| 978 individuals	PGP000498 \| Clark R et al. EBioMedicine (2023)	Reported Trait: Moderate myopia	—	AUROC: 0.66 [0.621, 0.699]	—	—	—
PPM018731	PGS003860 (PGS_RE)	PSS011078\| African Ancestry\| 4,089 individuals	PGP000498 \| Clark R et al. EBioMedicine (2023)	Reported Trait: High myopia (HM5)	—	AUROC: 0.586 [0.542, 0.629]	—	—	—
PPM018740	PGS003860 (PGS_RE)	PSS011082\| European Ancestry\| 1,277 individuals	PGP000498 \| Clark R et al. EBioMedicine (2023)	Reported Trait: Moderate hyperopia	—	AUROC: 0.765 [0.695, 0.825]	—	—	—
PPM018741	PGS003860 (PGS_RE)	PSS011081\| European Ancestry\| 1,649 individuals	PGP000498 \| Clark R et al. EBioMedicine (2023)	Reported Trait: Moderate hyperopia	—	AUROC: 0.774 [0.698, 0.845]	—	—	—
PPM018732	PGS003860 (PGS_RE)	PSS011083\| South Asian Ancestry\| 4,641 individuals	PGP000498 \| Clark R et al. EBioMedicine (2023)	Reported Trait: High myopia (HM5)	—	AUROC: 0.695 [0.664, 0.726]	—	—	—
PPM018735	PGS003860 (PGS_RE)	PSS011078\| African Ancestry\| 4,089 individuals	PGP000498 \| Clark R et al. EBioMedicine (2023)	Reported Trait: High myopia (HM6)	—	AUROC: 0.584 [0.53, 0.639]	—	—	—
PPM018714	PGS003860 (PGS_RE)	PSS011080\| European Ancestry\| 6,000 individuals	PGP000498 \| Clark R et al. EBioMedicine (2023)	Reported Trait: Refractive error	—	—	R²: 0.19 [0.172, 0.208]	—	—
PPM018715	PGS003860 (PGS_RE)	PSS011078\| African Ancestry\| 4,089 individuals	PGP000498 \| Clark R et al. EBioMedicine (2023)	Reported Trait: Refractive error	—	—	R²: 0.02 [0.012, 0.029]	—	—
PPM018716	PGS003860 (PGS_RE)	PSS011083\| South Asian Ancestry\| 4,641 individuals	PGP000498 \| Clark R et al. EBioMedicine (2023)	Reported Trait: Refractive error	—	—	R²: 0.08 [0.066, 0.096]	—	—
PPM018717	PGS003860 (PGS_RE)	PSS011079\| East Asian Ancestry\| 978 individuals	PGP000498 \| Clark R et al. EBioMedicine (2023)	Reported Trait: Refractive error	—	—	R²: 0.06 [0.034, 0.092]	—	—
PPM018718	PGS003860 (PGS_RE)	PSS011080\| European Ancestry\| 6,000 individuals	PGP000498 \| Clark R et al. EBioMedicine (2023)	Reported Trait: Moderate hyperopia	—	AUROC: 0.742 [0.718, 0.766]	—	—	—
PPM018719	PGS003860 (PGS_RE)	PSS011078\| African Ancestry\| 4,089 individuals	PGP000498 \| Clark R et al. EBioMedicine (2023)	Reported Trait: Moderate hyperopia	—	AUROC: 0.61 [0.543, 0.677]	—	—	—
PPM018720	PGS003860 (PGS_RE)	PSS011083\| South Asian Ancestry\| 4,641 individuals	PGP000498 \| Clark R et al. EBioMedicine (2023)	Reported Trait: Moderate hyperopia	—	AUROC: 0.676 [0.631, 0.721]	—	—	—
PPM018721	PGS003860 (PGS_RE)	PSS011079\| East Asian Ancestry\| 978 individuals	PGP000498 \| Clark R et al. EBioMedicine (2023)	Reported Trait: Moderate hyperopia	—	AUROC: 0.61 [0.415, 0.805]	—	—	—
PPM018733	PGS003860 (PGS_RE)	PSS011079\| East Asian Ancestry\| 978 individuals	PGP000498 \| Clark R et al. EBioMedicine (2023)	Reported Trait: High myopia (HM5)	—	AUROC: 0.648 [0.601, 0.694]	—	—	—
PPM018734	PGS003860 (PGS_RE)	PSS011080\| European Ancestry\| 6,000 individuals	PGP000498 \| Clark R et al. EBioMedicine (2023)	Reported Trait: High myopia (HM6)	—	AUROC: 0.783 [0.754, 0.812]	—	—	—
PPM018724	PGS003860 (PGS_RE)	PSS011083\| South Asian Ancestry\| 4,641 individuals	PGP000498 \| Clark R et al. EBioMedicine (2023)	Reported Trait: Low myopia	—	AUROC: 0.647 [0.631, 0.664]	—	—	—
PPM018730	PGS003860 (PGS_RE)	PSS011080\| European Ancestry\| 6,000 individuals	PGP000498 \| Clark R et al. EBioMedicine (2023)	Reported Trait: High myopia (HM5)	—	AUROC: 0.774 [0.75, 0.798]	—	—	—
PPM018738	PGS003860 (PGS_RE)	PSS011082\| European Ancestry\| 1,277 individuals	PGP000498 \| Clark R et al. EBioMedicine (2023)	Reported Trait: Refractive error	—	—	R²: 0.116 [0.079, 0.153]	—	—
PPM018742	PGS003860 (PGS_RE)	PSS011082\| European Ancestry\| 1,277 individuals	PGP000498 \| Clark R et al. EBioMedicine (2023)	Reported Trait: Low myopia	—	AUROC: 0.703 [0.654, 0.751]	—	—	—
PPM018743	PGS003860 (PGS_RE)	PSS011081\| European Ancestry\| 1,649 individuals	PGP000498 \| Clark R et al. EBioMedicine (2023)	Reported Trait: Low myopia	—	AUROC: 0.691 [0.659, 0.722]	—	—	—
PPM018744	PGS003860 (PGS_RE)	PSS011082\| European Ancestry\| 1,277 individuals	PGP000498 \| Clark R et al. EBioMedicine (2023)	Reported Trait: Moderate myopia	—	AUROC: 0.735 [0.6, 0.854]	—	—	—
PPM018745	PGS003860 (PGS_RE)	PSS011081\| European Ancestry\| 1,649 individuals	PGP000498 \| Clark R et al. EBioMedicine (2023)	Reported Trait: Moderate myopia	—	AUROC: 0.691 [0.624, 0.754]	—	—	—
PPM018746	PGS003860 (PGS_RE)	PSS011082\| European Ancestry\| 1,277 individuals	PGP000498 \| Clark R et al. EBioMedicine (2023)	Reported Trait: High myopia (HM5)	—	AUROC: 0.579 [0.567, 0.592]	—	—	—
PPM018747	PGS003860 (PGS_RE)	PSS011081\| European Ancestry\| 1,649 individuals	PGP000498 \| Clark R et al. EBioMedicine (2023)	Reported Trait: High myopia (HM6)	—	AUROC: 0.739 [0.619, 0.851]	—	—	—
PPM018748	PGS003860 (PGS_RE)	PSS011081\| European Ancestry\| 1,649 individuals	PGP000498 \| Clark R et al. EBioMedicine (2023)	Reported Trait: High myopia (HM6)	—	AUROC: 0.783 [0.754, 0.812]	—	—	—
PPM018749	PGS003860 (PGS_RE)	PSS011089\| Ancestry Not Reported\| 6,119 individuals	PGP000498 \| Clark R et al. EBioMedicine (2023)	Reported Trait: Refractive error	—	—	R²: 0.05 [0.04, 0.06]	—	—
PPM018750	PGS003860 (PGS_RE)	PSS011088\| Ancestry Not Reported\| 4,037 individuals	PGP000498 \| Clark R et al. EBioMedicine (2023)	Reported Trait: Refractive error	—	—	R²: 0.12 [0.1, 0.14]	—	—

Evaluated Samples

PGS Sample Set ID (PSS)	Phenotype Definitions and Methods	Participant Follow-up Time	Sample Numbers	Age of Study Participants	Sample Ancestry	Additional Ancestry Description	Cohort(s)	Additional Sample/Cohort Information
PSS011078	—	—	4,089 individuals	—	African unspecified	—	UKB	—
PSS011079	—	—	978 individuals	—	East Asian	—	UKB	—
PSS011080	—	—	6,000 individuals	—	European	—	UKB	—
PSS011081	—	—	1,649 individuals, 48.7 % Male samples	Mean = 13.62 years Sd = 0.36 years	European	—	Generation_R	—
PSS011082	—	—	1,277 individuals, 50.4 % Male samples	Mean = 9.83 years Sd = 0.35 years	European	—	Generation_R	—
PSS011083	—	—	4,641 individuals	—	South Asian	—	UKB	—
PSS011088	—	—	4,037 individuals, 47.2 % Male samples	Mean = 15.43 years Sd = 0.28 years	Not reported	—	ALSPAC	—
PSS011089	—	—	6,119 individuals, 50.7 % Male samples	Mean = 7.53 years Sd = 0.31 years	Not reported	—	ALSPAC	—

Publication Information (EuropePMC)
Title	A new polygenic score for refractive error improves detection of children at risk of high myopia but not the prediction of those at risk of myopic macular degeneration.
PubMed ID	37055258(Europe PMC)
doi	10.1016/j.ebiom.2023.104551
Publication Date	April 11, 2023
Journal	*EBioMedicine*
Author(s)	Clark R, Lee SS, Du R, Wang Y, Kneepkens SCM, Charng J, Huang Y, Hunter ML, Jiang C, Tideman JWL, Melles RB, Klaver CCW, Mackey DA, Williams C, Choquet H, Ohno-Matsui K, Guggenheim JA, CREAM Consortium, UK Biobank Eye and Vision Consortium.

PGS Publication: PGP000498

Associated Polygenic Score(s)

PGS Developed By This Publication

Performance Metrics

Evaluated Samples