PGS Publication: PGP000511

Publication Information (EuropePMC)
Title Genome-wide association analysis and Mendelian randomization proteomics identify drug targets for heart failure.
PubMed ID 37429843(Europe PMC)
doi 10.1038/s41467-023-39253-3
Publication Date July 10, 2023
Journal Nat Commun
Author(s) Rasooly D, Peloso GM, Pereira AC, Dashti H, Giambartolomei C, Wheeler E, Aung N, Ferolito BR, Pietzner M, Farber-Eger EH, Wells QS, Kosik NM, Gaziano L, Posner DC, Bento AP, Hui Q, Liu C, Aragam K, Wang Z, Charest B, Huffman JE, Wilson PWF, Phillips LS, Whittaker J, Munroe PB, Petersen SE, Cho K, Leach AR, Magariños MP, Gaziano JM, VA Million Veteran Program, Langenberg C, Sun YV, Joseph J, Casas JP.
Released in PGS Catalog: Oct. 17, 2023

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS003969
(PRS39_HF)
 PGP000511 |
Rasooly D et al. Nat Commun (2023)
 Heart failure heart failure 39
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003969/ScoringFiles/PGS003969.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM019123 PGS003969
(PRS39_HF)
 PSS011190|
European Ancestry|
75,119 individuals
 PGP000511 |
Rasooly D et al. Nat Commun (2023)
 Reported Trait: Heart failure OR: 1.28 [1.24, 1.31] — — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011190 — —
[
  • 5,845 cases
  • , 69,274 controls
]
,
43.9 % Male samples
 — European — BioVU —