PGS Publication: PGP000522

Publication Information (EuropePMC)
Title Sleep patterns, genetic susceptibility, and risk of new-onset gout: The UK Biobank prospective cohort study.
PubMed ID 37244070(Europe PMC)
doi 10.1016/j.jpsychores.2023.111381
Publication Date May 18, 2023
Journal J Psychosom Res
Author(s) Wu Q, He P, Ye Z, Zhou C, Liu M, Yang S, Zhang Y, Gan X, Zhang Y, Qin X.
Released in PGS Catalog: Dec. 15, 2023

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS004222
(GRS13_gout)
 PGP000522 |
Wu Q et al. J Psychosom Res (2023)
 Gout gout 13
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004222/ScoringFiles/PGS004222.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM020157 PGS004222
(GRS13_gout)
 PSS011298|
Multi-ancestry (including European)|
403,630 individuals
 PGP000522 |
Wu Q et al. J Psychosom Res (2023)
 Reported Trait: Incident gout — — p (interaction between PRS and sleep pattern): 0.043 Age, sex, race, Townsend deprivation index (TDI), body mass index (BMI), smoking and drinking status, history of hypertension and diabetes, uric acid, total cholesterol, estimated glomerular filtration rate (eGFR) levels, the use of diuretics medications —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011298 — — 382,477 individuals — European — UKB —
PSS011298 — — 21,153 individuals — Not reported — UKB —