PGS Publication: PGP000526

Publication Information (EuropePMC)
Title Polygenic Risk Score, Lifestyles, and Type 2 Diabetes Risk: A Prospective Chinese Cohort Study.
PubMed ID 37432247(Europe PMC)
doi 10.3390/nu15092144
Publication Date April 29, 2023
Journal Nutrients
Author(s) Liu J, Wang L, Cui X, Shen Q, Wu D, Yang M, Dong Y, Liu Y, Chen H, Yang Z, Liu Y, Zhu M, Ma H, Jin G, Qian Y.
Released in PGS Catalog: Dec. 15, 2023

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS004225
(PRS46_T2DEastAsia)
 PGP000526 |
Liu J et al. Nutrients (2023)
 Type 2 diabetes type 2 diabetes mellitus 46
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004225/ScoringFiles/PGS004225.txt.gz
PGS004226
(PRS50_T2DEur)
 PGP000526 |
Liu J et al. Nutrients (2023)
 Type 2 diabetes type 2 diabetes mellitus 50
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004226/ScoringFiles/PGS004226.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM020217 PGS004225
(PRS46_T2DEastAsia)
 PSS011306|
East Asian Ancestry|
5,024 individuals
 PGP000526 |
Liu J et al. Nutrients (2023)
 Reported Trait: Type 2 diabetes with lifestyle group — — Hazard ratio (HR, poor lifestyle and high PRS vs. ideal lifestyle and low PRS): 3.93 [2.07, 7.44] — —
PPM020215 PGS004225
(PRS46_T2DEastAsia)
 PSS011306|
East Asian Ancestry|
5,024 individuals
 PGP000526 |
Liu J et al. Nutrients (2023)
 Reported Trait: Type 2 diabetes — — Hazard ratio (HR, high vs low quintile): 2.06 [1.42, 2.97] age, gender, SBP, DBP, FBG, TC, TG, HDLC, and diabetes family history —
PPM020216 PGS004226
(PRS50_T2DEur)
 PSS011306|
East Asian Ancestry|
5,024 individuals
 PGP000526 |
Liu J et al. Nutrients (2023)
 Reported Trait: Type 2 diabetes — — Hazard ratio (HR, high vs low quintile): 1.69 [1.17, 2.44] age, gender, SBP, DBP, FBG, TC, TG, HDLC, and diabetes family history —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011306 — — 5,024 individuals,
40.0 % Male samples
 — East Asian
(Chinese)		 — Wuxi NCDs —