PGS Publication: PGP000529

Publication Information (EuropePMC)
Title Polygenic Susceptibility to Hypertension and Blood Pressure Control in Stroke Survivors.
PubMed ID 36690452(Europe PMC)
doi 10.1212/wnl.0000000000206763
Publication Date Jan. 23, 2023
Journal Neurology
Author(s) Acosta JN, Both CP, Demarais ZS, Conlon CJ, Leasure AC, Torres-Lopez VM, de Havenon A, Petersen NH, Gill TM, Sansing LH, Sheth KN, Falcone GJ.
Released in PGS Catalog: Dec. 15, 2023

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS004232
(PRS732_DBP)
 PGP000529 |
Acosta JN et al. Neurology (2023)
 Diastolic blood pressure diastolic blood pressure 732
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004232/ScoringFiles/PGS004232.txt.gz
PGS004231
(PRS732_SBP)
 PGP000529 |
Acosta JN et al. Neurology (2023)
 Systolic blood pressure systolic blood pressure 732
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004231/ScoringFiles/PGS004231.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM020229 PGS004231
(PRS732_SBP)
 PSS011310|
European Ancestry|
1,750 individuals
 PGP000529 |
Acosta JN et al. Neurology (2023)
 Reported Trait: Systolic blood pressure — — Beta (beta, top PRS quintile vs bottom PRS quintile): 3.62 (1.39) — —
PPM020230 PGS004231
(PRS732_SBP)
 PSS011310|
European Ancestry|
1,750 individuals
 PGP000529 |
Acosta JN et al. Neurology (2023)
 Reported Trait: Resistant blood pressure — — Odds ratio (OR, top PRS quintile vs bottom PRS quintile): 2.27 [1.3, 4.1] — —
PPM020232 PGS004231
(PRS732_SBP)
 PSS011309|
European Ancestry|
408,475 individuals
 PGP000529 |
Acosta JN et al. Neurology (2023)
 Reported Trait: Systolic blood pressure in all stroke — — Beta (beta, top PRS quintile vs bottom PRS quintile): 5.97 (0.76) age, sex, and vascular risk factors —
PPM020233 PGS004231
(PRS732_SBP)
 PSS011309|
European Ancestry|
408,475 individuals
 PGP000529 |
Acosta JN et al. Neurology (2023)
 Reported Trait: Uncontrolled blood pressure in all stroke — — Odds ratio (OR, top PRS quintile vs bottom PRS quintile): 1.71 [1.45, 2.03] age, sex, and vascular risk factors —
PPM020231 PGS004232
(PRS732_DBP)
 PSS011310|
European Ancestry|
1,750 individuals
 PGP000529 |
Acosta JN et al. Neurology (2023)
 Reported Trait: Resistant blood pressure — — Odds ratio (OR, top PRS quintile vs bottom PRS quintile): 1.56 [0.92, 2.7] — —
PPM020234 PGS004231
(PRS732_SBP)
 PSS011309|
European Ancestry|
408,475 individuals
 PGP000529 |
Acosta JN et al. Neurology (2023)
 Reported Trait: Resistant blood pressure in all stroke — — Odds ratio (OR, top PRS quintile vs bottom PRS quintile): 2.25 [1.59, 3.25] age, sex, and vascular risk factors —
PPM020235 PGS004232
(PRS732_DBP)
 PSS011309|
European Ancestry|
408,475 individuals
 PGP000529 |
Acosta JN et al. Neurology (2023)
 Reported Trait: Systolic blood pressure in all stroke — — Beta (beta, top PRS quintile vs bottom PRS quintile): 3.52 (0.42) age, sex, and vascular risk factors —
PPM020236 PGS004232
(PRS732_DBP)
 PSS011309|
European Ancestry|
408,475 individuals
 PGP000529 |
Acosta JN et al. Neurology (2023)
 Reported Trait: Uncontrolled blood pressure in all stroke — — Odds ratio (OR, top PRS quintile vs bottom PRS quintile): 1.6 [1.35, 1.89] age, sex, and vascular risk factors —
PPM020237 PGS004232
(PRS732_DBP)
 PSS011309|
European Ancestry|
408,475 individuals
 PGP000529 |
Acosta JN et al. Neurology (2023)
 Reported Trait: Resistant blood pressure in all stroke — — Odds ratio (OR, top PRS quintile vs bottom PRS quintile): 2.24 [1.6, 3.19] age, sex, and vascular risk factors —
PPM020238 PGS004231
(PRS732_SBP)
 PSS011309|
European Ancestry|
408,475 individuals
 PGP000529 |
Acosta JN et al. Neurology (2023)
 Reported Trait: Systolic blood pressure in Ischemic stroke — — Beta (beta, top PRS quintile vs bottom PRS quintile): 4.89 (1.51) age, sex, and vascular risk factors —
PPM020240 PGS004231
(PRS732_SBP)
 PSS011309|
European Ancestry|
408,475 individuals
 PGP000529 |
Acosta JN et al. Neurology (2023)
 Reported Trait: Resistant blood pressure in Ischemic stroke — — Odds ratio (OR, top PRS quintile vs bottom PRS quintile): 2.65 [1.39, 5.35] age, sex, and vascular risk factors —
PPM020241 PGS004232
(PRS732_DBP)
 PSS011309|
European Ancestry|
408,475 individuals
 PGP000529 |
Acosta JN et al. Neurology (2023)
 Reported Trait: Systolic blood pressure in Ischemic stroke — — Beta (beta, top PRS quintile vs bottom PRS quintile): 2.96 (0.84) age, sex, and vascular risk factors —
PPM020242 PGS004232
(PRS732_DBP)
 PSS011309|
European Ancestry|
408,475 individuals
 PGP000529 |
Acosta JN et al. Neurology (2023)
 Reported Trait: Uncontrolled blood pressure in Ischemic stroke — — Odds ratio (OR, top PRS quintile vs bottom PRS quintile): 1.45 [1.03, 2.03] age, sex, and vascular risk factors —
PPM020243 PGS004232
(PRS732_DBP)
 PSS011309|
European Ancestry|
408,475 individuals
 PGP000529 |
Acosta JN et al. Neurology (2023)
 Reported Trait: Resistant blood pressure in Ischemic stroke — — Odds ratio (OR, top PRS quintile vs bottom PRS quintile): 3.0 [1.62, 5.88] age, sex, and vascular risk factors —
PPM020244 PGS004231
(PRS732_SBP)
 PSS011309|
European Ancestry|
408,475 individuals
 PGP000529 |
Acosta JN et al. Neurology (2023)
 Reported Trait: Systolic blood pressure in Hemorrhagic stroke — — Beta (beta, top PRS quintile vs bottom PRS quintile): 4.84 (1.91) age, sex, and vascular risk factors —
PPM020245 PGS004231
(PRS732_SBP)
 PSS011309|
European Ancestry|
408,475 individuals
 PGP000529 |
Acosta JN et al. Neurology (2023)
 Reported Trait: Uncontrolled blood pressure in Hemorrhagic stroke — — Odds ratio (OR, top PRS quintile vs bottom PRS quintile): 2.17 [1.41, 3.36] age, sex, and vascular risk factors —
PPM020246 PGS004231
(PRS732_SBP)
 PSS011309|
European Ancestry|
408,475 individuals
 PGP000529 |
Acosta JN et al. Neurology (2023)
 Reported Trait: Resistant blood pressure in Hemorrhagic stroke — — Odds ratio (OR, top PRS quintile vs bottom PRS quintile): 1.77 [0.69, 4.97] age, sex, and vascular risk factors —
PPM020247 PGS004232
(PRS732_DBP)
 PSS011309|
European Ancestry|
408,475 individuals
 PGP000529 |
Acosta JN et al. Neurology (2023)
 Reported Trait: Systolic blood pressure in Hemorrhagic stroke — — Beta (beta, top PRS quintile vs bottom PRS quintile): 3.66 (1.08) age, sex, and vascular risk factors —
PPM020248 PGS004232
(PRS732_DBP)
 PSS011309|
European Ancestry|
408,475 individuals
 PGP000529 |
Acosta JN et al. Neurology (2023)
 Reported Trait: Uncontrolled blood pressure in Hemorrhagic stroke — — Odds ratio (OR, top PRS quintile vs bottom PRS quintile): 2.63 [1.71, 4.1] age, sex, and vascular risk factors —
PPM020249 PGS004232
(PRS732_DBP)
 PSS011309|
European Ancestry|
408,475 individuals
 PGP000529 |
Acosta JN et al. Neurology (2023)
 Reported Trait: Resistant blood pressure in Hemorrhagic stroke — — Odds ratio (OR, top PRS quintile vs bottom PRS quintile): 2.24 [0.84, 6.73] age, sex, and vascular risk factors —
PPM020239 PGS004231
(PRS732_SBP)
 PSS011309|
European Ancestry|
408,475 individuals
 PGP000529 |
Acosta JN et al. Neurology (2023)
 Reported Trait: Uncontrolled blood pressure in Ischemic stroke — — Odds ratio (OR, top PRS quintile vs bottom PRS quintile): 1.73 [1.23, 2.43] age, sex, and vascular risk factors —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011309 — — 408,475 individuals,
59.0 % Male samples
 Mean = 61.0 years
Sd = 7.0 years		 European — UKB —
PSS011310 — — 1,750 individuals,
65.0 % Male samples
 Mean = 68.0 years
Sd = 11.0 years		 European — VISP —