PGS Publication: PGP000532

Publication Information (EuropePMC)
Title Polygenic Risk Score for Coronary Artery Disease Improves the Prediction of Early-Onset Myocardial Infarction and Mortality in Men.
PubMed ID 34670400(Europe PMC)
doi 10.1161/circgen.121.003452
Publication Date Oct. 21, 2021
Journal Circ Genom Precis Med
Author(s) Manikpurage HD, Eslami A, Perrot N, Li Z, Couture C, Mathieu P, Bossé Y, Arsenault BJ, Thériault S.
Released in PGS Catalog: Dec. 15, 2023

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS004237
(CAD_PRS_LDpred_UKB_Pub1)
 PGP000532 |
Manikpurage HD et al. Circ Genom Precis Med (2021)
 Coronary Artery Disease coronary artery disease 1,146,511
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004237/ScoringFiles/PGS004237.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM020258 PGS004237
(CAD_PRS_LDpred_UKB_Pub1)
 PSS011313|
European Ancestry|
403,422 individuals
 PGP000532 |
Manikpurage HD et al. Circ Genom Precis Med (2021)
 Reported Trait: Prevalent Coronary Artery Disease OR: 1.56 [1.56, 1.58] AUROC: 0.766 R²: 0.158 Age, Sex and Genetic Principal Components (1 to 10) —
PPM020259 PGS004237
(CAD_PRS_LDpred_UKB_Pub1)
 PSS011313|
European Ancestry|
403,422 individuals
 PGP000532 |
Manikpurage HD et al. Circ Genom Precis Med (2021)
 Reported Trait: Prevalent Myocardial Infarction OR: 1.63 [1.6, 1.65] AUROC: 0.772 R²: 0.129 Age, Sex and Genetic Principal Components (1 to 10) —
PPM020260 PGS004237
(CAD_PRS_LDpred_UKB_Pub1)
 PSS011313|
European Ancestry|
403,422 individuals
 PGP000532 |
Manikpurage HD et al. Circ Genom Precis Med (2021)
 Reported Trait: Prevalent Myocardial Infarction and Coronary Revascularization procedure OR: 1.73 [1.7, 1.76] AUROC: 0.789 R²: 0.162 Age, Sex and Genetic Principal Components (1 to 10) —
PPM020261 PGS004237
(CAD_PRS_LDpred_UKB_Pub1)
 PSS011313|
European Ancestry|
403,422 individuals
 PGP000532 |
Manikpurage HD et al. Circ Genom Precis Med (2021)
 Reported Trait: Incident Myocardial Infarction HR: 1.53 [1.49, 1.56] C-index: 0.729 — Age, Sex and Genetic Principal Components (1 to 10) —
PPM020262 PGS004237
(CAD_PRS_LDpred_UKB_Pub1)
 PSS011313|
European Ancestry|
403,422 individuals
 PGP000532 |
Manikpurage HD et al. Circ Genom Precis Med (2021)
 Reported Trait: Mortality HR: 1.08 [1.06, 1.09] — — Age, Sex and Genetic Principal Components (1 to 10) —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011313 To define prevalent CAD, we selected participants with ICD-10 codes for MI (I21.X, I22.X, I23.X, I24.1, or I25.2), for other acute ischemic heart disease (I24.0, I24.8-9) and for atherosclerotic / chronic ischemic heart disease (I25.0-25.1, I25.5-25.9). Procedure codes for coronary artery bypass grafting (K40.1-40.4, K41.1-41.4, K45.1-45.5), for coronary angioplasty, with or without stenting (K49.1-49.2, K49.8-49.9, K50.2, K75.1-75.4, K75.8-75.9) were also added to the CAD definition. Mean = 11.0 years
[
  • 32,475 cases
  • , 370,947 controls
]
,
46.0 % Male samples
 Mean = 56.93 years European
(White British)		 — UKB —