PGS Publication: PGP000543

Publication Information (EuropePMC)
Title Socioeconomic Deprivation, Genetic Risk, and Incident Dementia.
PubMed ID 37085245(Europe PMC)
doi 10.1016/j.amepre.2023.01.012
Publication Date March 6, 2023
Journal Am J Prev Med
Author(s) Klee M, Leist AK, Veldsman M, Ranson JM, Llewellyn DJ.
Released in PGS Catalog: Dec. 15, 2023

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Additional Diverse Ancestries
Not Reported

External PGS Evaluated By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS002249
(AD_PRS_0.5)
 PGP000276 |
Lourida I et al. JAMA (2019)
 Alzheimer's disease Alzheimer disease 249,273
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002249/ScoringFiles/PGS002249.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM020316 PGS002249
(AD_PRS_0.5)
 PSS011330|
European Ancestry|
196,368 individuals
 PGP000543 |
Klee M et al. Am J Prev Med (2023)
|Ext.		 Reported Trait: Incident dementia with area-level socioeconomic deprivation — — Hazard ratio (HR, high deprivation and PRS in top quintile vs. low-moderate deprivation and PRS in bottom quintile): 2.31 [1.84, 2.91] 20 first PCs, third-degree relatedness, number of alleles used to compute PRS, age, sex, education, marital status, healthy lifestyle, depressive symptoms in the last 2 weeks, individual-level deprivation —
PPM020317 PGS002249
(AD_PRS_0.5)
 PSS011330|
European Ancestry|
196,368 individuals
 PGP000543 |
Klee M et al. Am J Prev Med (2023)
|Ext.		 Reported Trait: Incident dementia with individual-level socioeconomic deprivation — — Hazard ratio (HR, high deprivation and PRS in top quintile vs. low-moderate deprivation and PRS in bottom quintile): 4.06 [2.63, 6.26] 20 first PCs, third-degree relatedness, number of alleles used to compute PRS, age, sex, education, marital status, healthy lifestyle, depressive symptoms in the last 2 weeks, area-level deprivation —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011330 — — 196,368 individuals,
47.3 % Male samples
 Mean = 64.1 years
Sd = 2.9 years		 European — UKB —