PGS Publication: PGP000544

Publication Information (EuropePMC)
Title Association of air pollution, genetic risk, and lifestyle with incident adult-onset asthma: A prospective cohort study.
PubMed ID 37080133(Europe PMC)
doi 10.1016/j.ecoenv.2023.114922
Publication Date April 18, 2023
Journal Ecotoxicol Environ Saf
Author(s) Zhu Y, Pan Z, Jing D, Liang H, Cheng J, Li D, Zhou X, Lin F, Liu H, Pan P, Zhang Y.
Released in PGS Catalog: Dec. 15, 2023

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS004252
(PRS212_asthma)
 PGP000544 |
Zhu Y et al. Ecotoxicol Environ Saf (2023)
 Asthma asthma 212
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004252/ScoringFiles/PGS004252.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM020318 PGS004252
(PRS212_asthma)
 PSS011331|
European Ancestry|
298,738 individuals
 PGP000544 |
Zhu Y et al. Ecotoxicol Environ Saf (2023)
 Reported Trait: Incident asthma HR: 1.59 [1.5, 1.69] — — age, sex, region, employment status, household income, educational level, Townsend deprivation index, smoking status, drinking status, diet, and physical activity, relatedness, number of alleles included in the polygenic risk score, and first 20 principal components of ancestry —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011331 — —
[
  • 5,725 cases
  • , 293,013 controls
]
,
48.2 % Male samples
 Mean = 56.62 years
Sd = 8.03 years		 European
(Irish, British)		 — UKB —