PGS Publication: PGP000548

Publication Information (EuropePMC)
Title Association of laxatives use with incident dementia and modifying effect of genetic susceptibility: a population-based cohort study with propensity score matching.
PubMed ID 36870957(Europe PMC)
doi 10.1186/s12877-023-03854-w
Publication Date March 4, 2023
Journal BMC Geriatr
Author(s) Feng J, Zheng N, Fan X, Li S, Jiang Y, Yi X, Yang H.
Released in PGS Catalog: Jan. 11, 2024

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS004318
(PRS29_dementia)
 PGP000548 |
Feng J et al. BMC Geriatr (2023)
 Dementia dementia 29
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004318/ScoringFiles/PGS004318.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM020398 PGS004318
(PRS29_dementia)
 PSS011350|
Multi-ancestry (including European)|
57,688 individuals
 PGP000548 |
Feng J et al. BMC Geriatr (2023)
 Reported Trait: Alzheimer's disease — — Hazard ratio (HR, high vs low PRS tertile): 4.11 [3.71, 4.54] Sex, age, ethnicity, socioeconomic status, education attainment, current employment status, smoking status, alcohol consumption, physical activity, diet, BMI, heart disease, stroke, diabetes, hypertension, depression, cholesterol levels, and constipation —
PPM020399 PGS004318
(PRS29_dementia)
 PSS011350|
Multi-ancestry (including European)|
57,688 individuals
 PGP000548 |
Feng J et al. BMC Geriatr (2023)
 Reported Trait: Vascular dementia — — Hazard ratio (HR, high vs low PRS tertile): 2.43 [2.15, 2.75] Sex, age, ethnicity, socioeconomic status, education attainment, current employment status, smoking status, alcohol consumption, physical activity, diet, BMI, heart disease, stroke, diabetes, hypertension, depression, cholesterol levels, and constipation —
PPM020400 PGS004318
(PRS29_dementia)
 PSS011350|
Multi-ancestry (including European)|
57,688 individuals
 PGP000548 |
Feng J et al. BMC Geriatr (2023)
 Reported Trait: Dementia with high laxatives exposure — — Hazard ratio (HR, high laxative use and PRS in top tertile vs no laxative use and PRS in bottom tertile): 4.09 [3.48, 4.81] Sex, age, ethnicity, socioeconomic status, education attainment, current employment status, smoking status, alcohol consumption, physical activity, diet, BMI, heart disease, stroke, diabetes, hypertension, depression, cholesterol levels, and constipation —
PPM020401 PGS004318
(PRS29_dementia)
 PSS011350|
Multi-ancestry (including European)|
57,688 individuals
 PGP000548 |
Feng J et al. BMC Geriatr (2023)
 Reported Trait: Alzheimer's disease with high laxatives exposure — — Hazard ratio (HR, high laxative use and PRS in top tertile vs no laxative use and PRS in bottom tertile): 4.62 [3.56, 6.0] Sex, age, ethnicity, socioeconomic status, education attainment, current employment status, smoking status, alcohol consumption, physical activity, diet, BMI, heart disease, stroke, diabetes, hypertension, depression, cholesterol levels, and constipation —
PPM020402 PGS004318
(PRS29_dementia)
 PSS011350|
Multi-ancestry (including European)|
57,688 individuals
 PGP000548 |
Feng J et al. BMC Geriatr (2023)
 Reported Trait: Vascular dementia with high laxatives exposure — — Hazard ratio (HR, high laxative use and PRS in top tertile vs no laxative use and PRS in bottom tertile): 3.27 [2.37, 4.51] Sex, age, ethnicity, socioeconomic status, education attainment, current employment status, smoking status, alcohol consumption, physical activity, diet, BMI, heart disease, stroke, diabetes, hypertension, depression, cholesterol levels, and constipation —
PPM020397 PGS004318
(PRS29_dementia)
 PSS011350|
Multi-ancestry (including European)|
57,688 individuals
 PGP000548 |
Feng J et al. BMC Geriatr (2023)
 Reported Trait: Dementia — — Hazard ratio (HR, high vs low PRS tertile): 2.76 [2.6, 2.93] Sex, age, ethnicity, socioeconomic status, education attainment, current employment status, smoking status, alcohol consumption, physical activity, diet, BMI, heart disease, stroke, diabetes, hypertension, depression, cholesterol levels, and constipation —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011350 — — 53,447 individuals — European — UKB Mean age of full combined ancestry cohort = 58 years
PSS011350 — — 1,118 individuals — African unspecified — UKB Mean age of full combined ancestry cohort = 58 years
PSS011350 — — 3,123 individuals — Asian unspecified, Not reported — UKB Mean age of full combined ancestry cohort = 58 years