PGS Publication: PGP000556

Publication Information (EuropePMC)
Title Mediterranean diet adherence is associated with lower dementia risk, independent of genetic predisposition: findings from the UK Biobank prospective cohort study.
PubMed ID 36915130(Europe PMC)
doi 10.1186/s12916-023-02772-3
Publication Date March 14, 2023
Journal BMC Med
Author(s) Shannon OM, Ranson JM, Gregory S, Macpherson H, Milte C, Lentjes M, Mulligan A, McEvoy C, Griffiths A, Matu J, Hill TR, Adamson A, Siervo M, Minihane AM, Muniz-Tererra G, Ritchie C, Mathers JC, Llewellyn DJ, Stevenson E.
Released in PGS Catalog: Jan. 11, 2024

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Additional Diverse Ancestries
Not Reported

External PGS Evaluated By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS002249
(AD_PRS_0.5)
 PGP000276 |
Lourida I et al. JAMA (2019)
 Alzheimer's disease Alzheimer disease 249,273
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002249/ScoringFiles/PGS002249.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM020431 PGS002249
(AD_PRS_0.5)
 PSS011359|
European Ancestry|
60,298 individuals
 PGP000556 |
Shannon OM et al. BMC Med (2023)
|Ext.		 Reported Trait: Dementia — — Hazard ratio (HR, top vs bottom PRS quintile): 1.224 [1.102, 1.36] — —
PPM020432 PGS002249
(AD_PRS_0.5)
 PSS011359|
European Ancestry|
60,298 individuals
 PGP000556 |
Shannon OM et al. BMC Med (2023)
|Ext.		 Reported Trait: Dementia x MedDiet adherence (MEDAS score) interaction HR: 1.042 [1.003, 1.082] — — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011359 Alzheimer's (ICD10: F00, F00.0, F00.1, F00.2, F00.9, G30, G30.0, G30.1, G30.8, G30.9), Vascular dementia (ICD10: F01, F01.0, F01.1, F01.2, F01.3, F01.8, F01.9, I67.3), Frontotemporal dementia (ICD10: F02.0, G31.0), all-cause dementia (ICD10: A81.0, F02, F02.1, F02.2, F02.3, F02.4, F02.8, F03, F05.1, F10.6, G31.1, G31.8) Mean = 9.1 years
Sd = 1.7 years		 60,298 individuals,
51.5 % Male samples
 Mean = 63.8 years
Sd = 2.7 years		 European — UKB —