PGS Publication: PGP000559

Publication Information (EuropePMC)
Title Association of oxidative stress, programmed cell death, GSTM1 gene polymorphisms, smoking and the risk of lung carcinogenesis: A two-step Mendelian randomization study.
PubMed ID 37143928(Europe PMC)
doi 10.3389/fphys.2023.1145129
Publication Date April 18, 2023
Journal Front Physiol
Author(s) Wang Y, Yang Q, Zheng L.
Released in PGS Catalog: Jan. 11, 2024

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS004325
(GRS19_LC)
 PGP000559 |
Wang Y et al. Front Physiol (2023)
 Lung cancer lung carcinoma 19
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004325/ScoringFiles/PGS004325.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM020438 PGS004325
(GRS19_LC)
 PSS011362|
European Ancestry|
308,490 individuals
 PGP000559 |
Wang Y et al. Front Physiol (2023)
 Reported Trait: Lung carcinogenesis (in smokers) — — Hazard ratio (HR, highest PRS quintile and heavy smokers vs lowest PRS quintile and never smokers): 4.63 [3.0, 7.13] Education, sex, genotype array, and the first ten important components —
PPM020439 PGS004325
(GRS19_LC)
 PSS011362|
European Ancestry|
308,490 individuals
 PGP000559 |
Wang Y et al. Front Physiol (2023)
 Reported Trait: Lung carcinogenesis — — Hazard ratio (HR, highest vs lowest PRS quintiles): 1.58 [1.21, 2.08] Education, sex, genotype array, the first ten primary components, quit time for smokers only, and pack-years for smokers —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011362 — —
[
  • 1,449 cases
  • , 307,041 controls
]
,
47.0 % Male samples
 — European — UKB —