PGS Publication: PGP000568

Publication Information (EuropePMC)
Title Predictive Utility of a Validated Polygenic Risk Score for Long-Term Risk of Coronary Heart Disease in Young and Middle-Aged Adults.
PubMed ID 35880530(Europe PMC)
doi 10.1161/circulationaha.121.058426
Publication Date July 26, 2022
Journal Circulation
Author(s) Khan SS, Page C, Wojdyla DM, Schwartz YY, Greenland P, Pencina MJ.
Released in PGS Catalog: Jan. 26, 2024

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

External PGS Evaluated By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000013
(GPS_CAD)
 PGP000006 |
Khera AV et al. Nat Genet (2018)
 Coronary artery disease coronary artery disease 6,630,150
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000013/ScoringFiles/PGS000013.txt.gz - Check Terms/Licenses

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM020713 PGS000013
(GPS_CAD)
 PSS011380|
European Ancestry|
1,863 individuals
 PGP000568 |
Khan SS et al. Circulation (2022)
|Ext.		 Reported Trait: Incident coronary heart diseaase HR: 1.82 [1.56, 2.12] — — 30-year traditional risk factor score linear predictor —
PPM020714 PGS000013
(GPS_CAD)
 PSS011379|
European Ancestry|
2,154 individuals
 PGP000568 |
Khan SS et al. Circulation (2022)
|Ext.		 Reported Trait: Incident coronary heart diseaase HR: 1.6 [1.43, 1.79] — — 30-year traditional risk factor score linear predictor —
PPM020715 PGS000013
(GPS_CAD)
 PSS011378|
European Ancestry|
5,740 individuals
 PGP000568 |
Khan SS et al. Circulation (2022)
|Ext.		 Reported Trait: Incident coronary heart diseaase HR: 1.16 [1.09, 1.23] — — 30-year traditional risk factor score linear predictor —
PPM020716 PGS000013
(GPS_CAD)
 PSS011380|
European Ancestry|
1,863 individuals
 PGP000568 |
Khan SS et al. Circulation (2022)
|Ext.		 Reported Trait: Incident coronary heart diseaase HR: 1.98 [1.7, 2.3] C-index: 0.73 — Age, sex —
PPM020717 PGS000013
(GPS_CAD)
 PSS011379|
European Ancestry|
2,154 individuals
 PGP000568 |
Khan SS et al. Circulation (2022)
|Ext.		 Reported Trait: Incident coronary heart diseaase HR: 1.64 [1.47, 1.84] C-index: 0.66 — Age, sex —
PPM020718 PGS000013
(GPS_CAD)
 PSS011378|
European Ancestry|
5,740 individuals
 PGP000568 |
Khan SS et al. Circulation (2022)
|Ext.		 Reported Trait: Incident coronary heart diseaase HR: 1.22 [1.15, 1.3] C-index: 0.66 — Age, sex —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011378 — — 5,740 individuals,
46.0 % Male samples
 Median = 52.0 years
IQR = [48.0, 56.0] years		 European — ARIC —
PSS011379 — — 2,154 individuals,
45.0 % Male samples
 Median = 43.0 years
IQR = [41.0, 45.0] years		 European — FOS —
PSS011380 — — 1,863 individuals,
46.0 % Male samples
 Median = 30.0 years
IQR = [26.0, 34.0] years		 European — FOS —