PGS Publication: PGP000578

Publication Information (EuropePMC)
Title Amyloid-β and APOE genotype predict memory decline in cognitively unimpaired older individuals independently of Alzheimer's disease polygenic risk score.
PubMed ID 36522743(Europe PMC)
doi 10.1186/s12883-022-02925-6
Publication Date Dec. 15, 2022
Journal BMC Neurol
Author(s) Tomassen J, den Braber A, van der Lee SJ, Reus LM, Konijnenberg E, Carter SF, Yaqub M, van Berckel BNM, Collij LE, Boomsma DI, de Geus EJC, Scheltens P, Herholz K, Tijms BM, Visser PJ.
Released in PGS Catalog: Jan. 26, 2024

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
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E - PGS Evaluation
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PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS004600
(PRS_AD83)
 PGP000578 |
Tomassen J et al. BMC Neurol (2022)
 Alzheimer's disease Alzheimer disease 83
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004600/ScoringFiles/PGS004600.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM020755 PGS004600
(PRS_AD83)
 PSS011392|
European Ancestry|
276 individuals
 PGP000578 |
Tomassen J et al. BMC Neurol (2022)
 Reported Trait: Memory function over time β: -0.04 (0.01) — — age, sex, center, education —
PPM020756 PGS004600
(PRS_AD83)
 PSS011392|
European Ancestry|
276 individuals
 PGP000578 |
Tomassen J et al. BMC Neurol (2022)
 Reported Trait: Positive amyloid-beta status OR: 1.43 [1.02, 2.0] — — age, sex, center, education —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011392 Used the following tests to assess memory performance: the total immediate recall and delayed recall of the Rey Auditory Verbal Learning Test (RAVLT), the twenty minute recall of the Rey Complex Figure Test (RCFT), the total errors of the Cambridge Neuropsychological Test Automated Battery (CANTAB) Paired Associate Learning (PAL) test, and the total score of the Face Name Associated Memory Examination (FNAME) names and occupations delayed recall. Mean = 2.0 years
Sd = 0.4 years		 276 individuals,
37.0 % Male samples
 Mean = 74.7 years
Sd = 9.7 years		 European — ACPRC, NTR Cognitively unimpaired. Includes 97 complete twin pairs.