PGS Publication: PGP000597

Publication Information (EuropePMC)
Title Cancer-associated thrombosis by cancer sites and inherited factors in a prospective population-based cohort.
PubMed ID 37419004(Europe PMC)
doi 10.1016/j.thromres.2023.06.023
Publication Date June 26, 2023
Journal Thromb Res
Author(s) Shi Z, Wei J, Rifkin AS, Wang CH, Billings LK, Woo JSH, Talamonti MS, Vogel TJ, Moore E, Brockstein BE, Khandekar JD, Dunnenberger HM, Hulick PJ, Duggan D, Zheng SL, Lee CJ, Helfand BT, Tafur AJ, Xu J.
Released in PGS Catalog: March 18, 2024

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

External PGS Evaluated By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS003332
(PRS_VTE_EUR_GHOUSE)
 PGP000398 |
Ghouse J et al. Nat Genet (2023)
 Venous thromboembolism venous thromboembolism 1,092,045
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003332/ScoringFiles/PGS003332.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM020880 PGS003332
(PRS_VTE_EUR_GHOUSE)
 PSS011439|
Multi-ancestry (including European)|
70,406 individuals
 PGP000597 |
Shi Z et al. Thromb Res (2023)
|Ext.		 Reported Trait: Incident cancer-associated thrombosis — — Hazard ratio (HR, top PRS decile vs rest): 1.75 [1.62, 1.88] Age, gender, BMI and 10 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011439 — — 68,709 individuals,
52.59 % Male samples
 Mean = 60.42 years
Ci = [60.37, 60.48] years		 European — UKB —
PSS011439 — — 105 individuals,
52.38 % Male samples
 Mean = 55.61 years
Ci = [54.11, 57.11] years		 African unspecified — UKB —
PSS011439 — — 730 individuals,
49.18 % Male samples
 Mean = 57.46 years
Ci = [56.89, 58.03] years		 Asian unspecified — UKB —
PSS011439 — — 862 individuals,
51.86 % Male samples
 Mean = 57.82 years
Ci = [57.28, 58.36] years		 Not reported — UKB —