PGS Publication: PGP000598

Publication Information (EuropePMC)
Title Low-level ambient sulfur dioxide exposure and genetic susceptibility associated with incidence of idiopathic pulmonary fibrosis: A national prospective cohort study.
PubMed ID 37414299(Europe PMC)
doi 10.1016/j.chemosphere.2023.139362
Publication Date July 4, 2023
Journal Chemosphere
Author(s) Wang X, Deng X, Wu Y, Qian Z, Cai M, Li H, Lin H.
Released in PGS Catalog: March 18, 2024

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS004695
(PRS23_IPF)
 PGP000598 |
Wang X et al. Chemosphere (2023)
 Idiopathic pulmonary fibrosis idiopathic pulmonary fibrosis 23
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004695/ScoringFiles/PGS004695.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM020881 PGS004695
(PRS23_IPF)
 PSS011440|
European Ancestry|
402,042 individuals
 PGP000598 |
Wang X et al. Chemosphere (2023)
 Reported Trait: Incident idiopathic pulmonary fibrosis — — Hazard ratio (HR, high vs low PRS quintile): 3.78 [3.3, 4.34] Age, sex, education level, smoking status, pack-years of smoking, BMI —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011440 — Median = 11.78 years
[
  • 2,589 cases
  • , 399,453 controls
]
,
46.66 % Male samples
 Mean = 56.41 years
Sd = 8.04 years		 European — UKB —