PGS Publication: PGP000611

Publication Information (EuropePMC)
Title Polygenic risk score for predicting weight loss after bariatric surgery.
PubMed ID 30185664(Europe PMC)
doi 10.1172/jci.insight.122011
Publication Date Sept. 6, 2018
Journal JCI Insight
Author(s) de Toro-Martín J, Guénard F, Tchernof A, Pérusse L, Marceau S, Vohl MC.
Released in PGS Catalog: April 18, 2024

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS004864
(PRS186_BMI)
 PGP000611 |
de Toro-Martín J et al. JCI Insight (2018)
 Body mass index (BMI) body mass index 186
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004864/ScoringFiles/PGS004864.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM021100 PGS004864
(PRS186_BMI)
 PSS011528|
Ancestry Not Reported|
767 individuals
 PGP000611 |
de Toro-Martín J et al. JCI Insight (2018)
 Reported Trait: Low weight loss following bariatric surgery — AUROC: 0.888 NRI: 0.638 [0.466, 0.809]
IDI: 0.066 [0.041, 0.091]		 Age, sex, initial body mass index, and type of surgery —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011528 Of the 767 participants, 147 were assigned to the low weight loss (LWL) trajectory group following biliopancreatic diversion with duodenal switch whilst 620 were assigned to the high weight loss and normal weight loss (HWL+NWL) trajectory group following biliopancreatic diversion with duodenal switch. Of the 147 individuals within the LWL trajectory group, 34 underwent biliopancreatic diversion with duodenal switch via laparoscopy whilst 112 underwent the same procedure via open surgery. Of the 620 individuals within the HWL+NWL trajectory group, 396 underwent biliopancreatic diversion with duodenal switch via laparoscopy whilst 217 underwent the same procedure via open surgery. On the eve of the surgery, height and body weight were measured and used to calculate the initial BMI as the weight in kilograms divided by the square of the height in meters. Body weight was further measured during postoperative visits or phone calls thorough a follow-up period of 8 years. Percentage of excess body weight loss (EBWL) was then calculated at each follow-up time point (3, 6, 12, 24, 36, 48, 60, 72, 84, and 96 months) as the difference between actual body weight loss (calculated initial BMI minus actual BMI) and ideal body weight loss (calculated as the initial BMI minus ideal BMI fixed at 25 kg/m2). — 767 individuals,
28.16 % Male samples
 — Not reported — NR Participants were obtained from the Bariatric Surgery Clinic of the Quebec Heart and Lung Institute.