PGS Publication: PGP000757

Publication Information (EuropePMC)
Title Genome-wide analysis of heart failure yields insights into disease heterogeneity and enables prognostic prediction in the Japanese population.
PubMed ID 41184235(Europe PMC)
doi 10.1038/s41467-025-64659-6
Publication Date Nov. 3, 2025
Journal Nat Commun
Author(s) Enzan N, Miyazawa K, Koyama S, Kurosawa R, Ieki H, Yoshida H, Takechi F, Fukuyama M, Osako R, Tomizuka K, Liu X, Ozaki K, Onouchi Y, BioBank Japan Project, Matsuda K, Momozawa Y, Aburatani H, Kamatani Y, Yamaguchi T, Akazawa H, Node K, Ellinor PT, Levin MG, Damrauer SM, Voight BF, Joseph J, Sun YV, Terao C, Ninomiya T, Komuro I, Ito K.
Released in PGS Catalog: Nov. 10, 2025

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS005285
(BBJ_HF_PRS_HG19)
 PGP000757 |
Enzan N et al. Nat Commun (2025)
 Heart failure heart failure 993,899
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005285/ScoringFiles/PGS005285.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM022992 PGS005285
(BBJ_HF_PRS_HG19)
 PSS012088|
East Asian Ancestry|
13,157 individuals
 PGP000757 |
Enzan N et al. Nat Commun (2025)
 Reported Trait: incident all-cause heart failure cases — — R²: 0.0737 — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012088 — —
[
  • 1,837 cases
  • , 11,320 controls
]
,
63.8 % Male samples
 Mean = 66.4 years East Asian
(Japanese)		 — BBJ —