PGS Publication: PGP000804

Publication Information (EuropePMC)
Title High polygenic risk score is a risk factor associated with colorectal cancer based on data from the UK Biobank.
PubMed ID 38032963(Europe PMC)
doi 10.1371/journal.pone.0295155
Publication Date Nov. 30, 2023
Journal PLoS One
Author(s) Yang M, Narasimhan VM, Zhan FB.
Released in PGS Catalog: May 7, 2026

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

External PGS Evaluated By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS002265
(PRS140_CRC)
 PGP000294 |
Thomas M et al. Am J Hum Genet (2020)
 Colorectal cancer colorectal cancer 140
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002265/ScoringFiles/PGS002265.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM030703 PGS002265
(PRS140_CRC)
 PSS012255|
European Ancestry|
11,947 individuals
 PGP000804 |
Yang M et al. PLoS One (2023)
|Ext.		 Reported Trait: Colorectal cancer OR: 2.7 [2.27, 3.19] — — age, BMI, IMD, sex, family history, current tobacci smoking, alcohol intake frequency, household income, number of vehicles in the household, maternal smoking around birth, eductaion employment —
PPM030704 PGS002265
(PRS140_CRC)
 PSS012256|
European Ancestry|
10,966 individuals
 PGP000804 |
Yang M et al. PLoS One (2023)
|Ext.		 Reported Trait: Colorectal cancer (50 years or olders) OR: 2.67 [2.24, 3.2] — — age, BMI, IMD, sex, PRS, family history, current tobacco smoking, alcohol intake frequency, household income, number vehicles in the household, maternal smoking around birth, education, employment —
PPM030705 PGS002265
(PRS140_CRC)
 PSS012257|
European Ancestry|
981 individuals
 PGP000804 |
Yang M et al. PLoS One (2023)
|Ext.		 Reported Trait: Colorectal cancer (<50 years) OR: 2.87 [1.65, 5.0] — — age, BMI, IMD, sex, PRS, family history, current tobacco smoking, alcohol intake frequency, household income, number vehicles in the household, maternal smoking around birth, education, employment —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012256 — —
[
  • 2,387 cases
  • , 8,579 controls
]
 — European — UKB —
PSS012257 — —
[
  • 198 cases
  • , 783 controls
]
 — European — UKB —
PSS012255 — —
[
  • 2,585 cases
  • , 9,362 controls
]
 — European — UKB —