PGS Publication: PGP000827

Publication Information (EuropePMC)
Title Polygenic risk score-based prediction of breast cancer risk in Taiwanese women with dense breast using a retrospective cohort study.
PubMed ID 38491043(Europe PMC)
doi 10.1038/s41598-024-55976-9
Publication Date March 15, 2024
Journal Sci Rep
Author(s) Hung CC, Moi SH, Huang HI, Hsiao TH, Huang CC.
Released in PGS Catalog: July 15, 2026

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Additional Asian Ancestries
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Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

External PGS Evaluated By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000001
(PRS77_BC)
 PGP000001 |
Mavaddat N et al. J Natl Cancer Inst (2015)
 Breast cancer breast carcinoma 77
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000001/ScoringFiles/PGS000001.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM036554 PGS000001
(PRS77_BC)
 PSS012310|
East Asian Ancestry|
6,335 individuals
 PGP000827 |
Hung CC et al. Sci Rep (2024)
|Ext.		 Reported Trait: Breast cancer — — Hazard ratio (HR, high vs low tertile): 1.86 [1.25, 2.75] Age at mammography, Family history of BC, Previous pregnancy, Breast surgery history, Benign breast disease, Self-exam experience, Breast symptoms, Others cancer, Age at menarche, Menopause, OC, HRT, Harrel's C-index —
PPM036555 PGS000001
(PRS77_BC)
 PSS012310|
East Asian Ancestry|
6,335 individuals
 PGP000827 |
Hung CC et al. Sci Rep (2024)
|Ext.		 Reported Trait: Breast cancer with no symptoms — — Hazard ratio (HR, high vs low tertile): 2.23 [1.41, 3.48] Age at mammography, Family history of BC, Previous pregnancy, Breast surgery history, Benign breast disease, Self-exam experience, Breast symptoms, Others cancer, Age at menarche, Menopause, OC, HRT, Harrel's C-index —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012310 — —
[
  • 111 cases
  • , 6,224 controls
]
,
0.0 % Male samples
 Mean = 57.4 years
Sd = 7.6 years		 East Asian — TPMI —