Polygenic Score (PGS) ID: PGS000013

Predicted Trait
Reported Trait Coronary artery disease
Mapped Trait(s) coronary artery disease (EFO_0001645)
Released in PGS Catalog: Oct. 14, 2019
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Terms and Licenses
Freely available to the academic community for research use. Parties interested in using the scores for commercial purposes should contact the Broad Office of Strategic Alliances and Partnering (partnering@broadinstitute.org).

Score Details

Score Construction
PGS Name GPS_CAD
Variants
Original Genome Build hg19
Number of Variants 6,630,150
Development Method
Name LDPred
Parameters ρ = 0.001; LD panel = 503 1000G Europeans
PGS Source
PGS Catalog Publication (PGP) ID PGP000006
Citation (link to publication) Khera AV et al. Nat Genet (2018)

Contributing Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry
GWAS Catalog: GCST003116
EuropePMC: 26343387
11,323 individuals East Asian
GWAS Catalog: GCST003116
EuropePMC: 26343387
25,557 individuals South Asian
GWAS Catalog: GCST003116
EuropePMC: 26343387
2,268 individuals Greater Middle Eastern (Middle Eastern, North African or Persian)
GWAS Catalog: GCST003116
EuropePMC: 26343387
4,095 individuals Hispanic or Latin American
GWAS Catalog: GCST003116
EuropePMC: 26343387
141,217 individuals European
GWAS Catalog: GCST003116
EuropePMC: 26343387
3,139 individuals African American or Afro-Caribbean
Score Development/Training
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
CAD ascertainment was based on a composite of myocardial infarction or coronary revascularization. Myocardial infarction was based on self-report or hospital admission diagnosis, as performed centrally. This included individuals with ICD-9 codes of 410.X, 411.0, 412.X, or 429.79, or ICD-10 codes of I21.X, I22.X, I23.X, I24.1, or I25.2 in hospitalization records. Coronary revascularization was assessed based on an OPCS-4 coded procedure for coronary artery bypass grafting (K40.1–40.4, K41.1–41.4, or K45.1–45.5), or coronary angioplasty with or without stenting (K49.1–49.2, K49.8–49.9, K50.2, K75.1–75.4, or K75.8–75.9).
[
  • 3,963 cases
  • , 116,317 controls
]
European UKB UKB Phase 1

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID
(PPM ID)
PGS Sample Set ID
(PSS ID)
Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in the Model PGS Performance: Other Relevant Information
PPM001620 PSS000837 PGP000129 Mosley JD et al. (2020) Ext. Reported Trait: Incident coronary heart disease (10-year risk) C-index: 0.7 [0.677, 0.721] Δ C-index (PRS+covariates vs. covariates alone): -0.001 [-0.009, 0.006] Pooled cohort risk percentile, age, sex, PCs (1-5)
PPM001011 PSS000515 PGP000116 Aragam KG et al. (2020) Ext. Reported Trait: Prevalent Coronary Artery Disease AUROC: 0.58 PCs (1-10) of ancestry
PPM001010 PSS000517 PGP000116 Aragam KG et al. (2020) Ext. Reported Trait: Prevalent Coronary Artery Disease AUROC: 0.63 PCs (1-10) of ancestry
PPM001009 PSS000516 PGP000116 Aragam KG et al. (2020) Ext. Reported Trait: Prevalent Coronary Artery Disease AUROC: 0.53 PCs (1-10) of ancestry
PPM001008 PSS000515 PGP000116 Aragam KG et al. (2020) Ext. Reported Trait: Prevalent Coronary Artery Disease OR: 1.29 [1.23, 1.34] age, sex, PCs (1-10) of ancestry
PPM001007 PSS000517 PGP000116 Aragam KG et al. (2020) Ext. Reported Trait: Prevalent Coronary Artery Disease OR: 1.5 [1.44, 1.57] age, sex, PCs (1-10) of ancestry
PPM001006 PSS000516 PGP000116 Aragam KG et al. (2020) Ext. Reported Trait: Prevalent Coronary Artery Disease OR: 1.52 [1.46, 1.58] age, sex, PCs (1-10) of ancestry
PPM001005 PSS000514 PGP000116 Aragam KG et al. (2020) Ext. Reported Trait: Prevalent Coronary Artery Disease AUROC: 0.61 PCs (1-10) of ancestry
PPM001004 PSS000519 PGP000116 Aragam KG et al. (2020) Ext. Reported Trait: Prevalent Coronary Artery Disease AUROC: 0.6 PCs (1-10) of ancestry
PPM001003 PSS000518 PGP000116 Aragam KG et al. (2020) Ext. Reported Trait: Prevalent Coronary Artery Disease AUROC: 0.59 PCs (1-10) of ancestry
PPM001002 PSS000514 PGP000116 Aragam KG et al. (2020) Ext. Reported Trait: Prevalent Coronary Artery Disease OR: 1.42 [1.35, 1.48] age, sex, PCs (1-10) of ancestry
PPM001001 PSS000519 PGP000116 Aragam KG et al. (2020) Ext. Reported Trait: Prevalent Coronary Artery Disease OR: 1.45 [1.38, 1.52] age, sex, PCs (1-10) of ancestry, genotyping array
PPM001000 PSS000518 PGP000116 Aragam KG et al. (2020) Ext. Reported Trait: Prevalent Coronary Artery Disease OR: 1.41 [1.34, 1.47] age, sex, PCs (1-10) of ancestry, genotyping array
PPM000999 PSS000520 PGP000116 Aragam KG et al. (2020) Ext. Reported Trait: Prevalent Coronary Artery Disease OR: 1.42 [1.38, 1.46] age, sex, PCs (1-10) of ancestry, genotyping array
PPM000596 PSS000336 PGP000083 Dikilitas O et al. (2020) Ext. Reported Trait: Incident coronary heart disease HR: 1.16 [0.96, 1.41] C-index: 0.659 sex, eMERGE site, first five ancestry-specific principal components Age-as-time-scale Cox regression
PPM000593 PSS000332 PGP000083 Dikilitas O et al. (2020) Ext. Reported Trait: Incident coronary heart disease HR: 1.19 [1.07, 1.33] C-index: 0.656 sex, eMERGE site, first five ancestry-specific principal components Age-as-time-scale Cox regression
PPM000619 PSS000332 PGP000083 Dikilitas O et al. (2020) Ext. Reported Trait: Incident coronary heart disease HR: 1.17 [1.04, 1.31] C-index: 0.712 sex, eMERGE site, diabetes, hypertension, hyperlipidemia, statin use, first 5 ancestry-specific principal components Age-as-time-scale Cox regression
PPM000615 PSS000334 PGP000083 Dikilitas O et al. (2020) Ext. Reported Trait: Incident coronary heart disease HR: 1.47 [1.41, 1.54] C-index: 0.75 sex, eMERGE site, diabetes, hypertension, hyperlipidemia, statin use, first 5 ancestry-specific principal components Age-as-time-scale Cox regression
PPM000623 PSS000336 PGP000083 Dikilitas O et al. (2020) Ext. Reported Trait: Incident coronary heart disease HR: 1.14 [0.94, 1.39] C-index: 0.708 sex, eMERGE site, diabetes, hypertension, hyperlipidemia, statin use, first 5 ancestry-specific principal components Age-as-time-scale Cox regression
PPM000590 PSS000334 PGP000083 Dikilitas O et al. (2020) Ext. Reported Trait: Incident coronary heart disease HR: 1.5 [1.43, 1.56] C-index: 0.719 sex, eMERGE site, first five ancestry-specific principal components Age-as-time-scale Cox regression
PPM000022 PSS000015 PGP000006 Khera AV et al. (2018) Reported Trait: Coronary artery disease AUROC: 0.81 [0.81, 0.81] Nagelkerke’s R2 (estimate of variance explained by the PGS after covariate adjustment): 0.04 age; sex; Ancestry PC 1-4; genotyping chip
PPM000030 PSS000021 PGP000008 Wünnemann F et al. (2019) Ext. Reported Trait: Coronary artery disease (prevalent) OR: 1.64 [1.48, 1.81] AUROC: 0.72 [0.7, 0.74] age, sex, first four genetic PCs
PPM000031 PSS000022 PGP000008 Wünnemann F et al. (2019) Ext. Reported Trait: Coronary artery disease (prevalent) OR: 1.55 [1.38, 1.73] AUROC: 0.89 [0.88, 0.91] age, sex, first four genetic PCs
PPM000032 PSS000019 PGP000008 Wünnemann F et al. (2019) Ext. Reported Trait: Coronary artery disease (prevalent) OR: 1.69 [1.44, 1.99] AUROC: 0.84 [0.81, 0.87] age, sex, first four genetic PCs, cohort recruitment centre
PPM000033 PSS000020 PGP000008 Wünnemann F et al. (2019) Ext. Reported Trait: Reccurent coronary artery disease events OR: 1.13 [1.06, 1.22] age, sex, first four genetic PCs
PPM000383 PSS000219 PGP000057 Homburger JR et al. (2019) Ext. Reported Trait: Coronary artery disease (personal history) OR: 1.589 [1.32, 1.92] AUROC: 0.86 age, sex
PPM000402 PSS000227 PGP000060 Khera AV et al. (2019) Ext. Reported Trait: Early-onset mycardial infarction (age ≤55 years) OR: 2.16 [1.35, 1.59] Odds Ratio (OR; top 5% vs. rest): 3.33 [0.82, 13.51] 4 genetic PCs
PPM000401 PSS000229 PGP000060 Khera AV et al. (2019) Ext. Reported Trait: Early-onset mycardial infarction (age ≤55 years) OR: 1.56 [1.29, 1.88] Odds Ratio (OR; top 5% vs. rest): 3.38 [2.03, 5.64] 4 genetic PCs
PPM000400 PSS000228 PGP000060 Khera AV et al. (2019) Ext. Reported Trait: Early-onset mycardial infarction (age ≤55 years) OR: 1.46 [1.28, 1.66] Odds Ratio (OR; top 5% vs. rest): 2.02 [1.29, 3.16] 4 genetic PCs
PPM000399 PSS000230 PGP000060 Khera AV et al. (2019) Ext. Reported Trait: Early-onset mycardial infarction (age ≤55 years) OR: 2.06 [1.89, 2.25] Odds Ratio (OR; top 5% vs. rest): 5.09 [3.82, 6.78] 4 genetic PCs
PPM000387 PSS000219 PGP000057 Homburger JR et al. (2019) Ext. Reported Trait: Coronary artery disease (personal history) AUROC: 0.6
PPM000933 PSS000469 PGP000108 Hindy G et al. (2020) Ext. Reported Trait: Incident coronary artery disease C-index: 0.768 [0.76, 0.776] age, sex, PCs (1-10), Pooled Cohort Equations risk estimator
PPM000932 PSS000469 PGP000108 Hindy G et al. (2020) Ext. Reported Trait: Incident coronary artery disease C-index: 0.756 [0.75, 0.762] age, sex, PCs (1-10)
PPM000929 PSS000468 PGP000108 Hindy G et al. (2020) Ext. Reported Trait: Incident coronary artery disease C-index: 0.802 [0.763, 0.8841] age, sex, PCs (1-10), Pooled Cohort Equations risk estimator
PPM000928 PSS000468 PGP000108 Hindy G et al. (2020) Ext. Reported Trait: Incident coronary artery disease C-index: 0.759 [0.724, 0.794] age, sex, PCs (1-10)
PPM000927 PSS000468 PGP000108 Hindy G et al. (2020) Ext. Reported Trait: Incident coronary artery disease HR: 1.45 [1.34, 1.56] age, sex, clinical risk factors (systolic blood pressure, diastolic blood pressure, apolipoprotein B, apolipoprotein A1, total cholesterol, LDL cholesterol, HDL cholesterol, body mass index, current smoker, diabetes), family history of CAD
PPM000930 PSS000469 PGP000108 Hindy G et al. (2020) Ext. Reported Trait: Incident coronary artery disease HR: 1.53 [1.49, 1.56] age, sex
PPM000926 PSS000467 PGP000108 Hindy G et al. (2020) Ext. Reported Trait: Incident coronary artery disease HR: 1.45 [1.4, 1.49] age, sex
PPM000931 PSS000469 PGP000108 Hindy G et al. (2020) Ext. Reported Trait: Incident coronary artery disease HR: 1.46 [1.42, 1.49] age, sex, clinical risk factors (systolic blood pressure, diastolic blood pressure, apolipoprotein B, apolipoprotein A1, total cholesterol, LDL cholesterol, HDL cholesterol, body mass index, current smoker, diabetes), family history of CAD
PPM000605 PSS000335 PGP000083 Dikilitas O et al. (2020) Ext. Reported Trait: Coronary heart disease (incident and prevalent) OR: 1.42 [1.25, 1.61] AUROC: 0.776 age at first EHR record, duration of EHR, sex, eMERGE site, first five ancestry-specific principal components
PPM000602 PSS000331 PGP000083 Dikilitas O et al. (2020) Ext. Reported Trait: Coronary heart disease (incident and prevalent) OR: 1.3 [1.21, 1.41] AUROC: 0.771 age at first EHR record, duration of EHR, sex, eMERGE site, first five ancestry-specific principal components
PPM000599 PSS000333 PGP000083 Dikilitas O et al. (2020) Ext. Reported Trait: Coronary heart disease (incident and prevalent) OR: 1.66 [1.62, 1.71] AUROC: 0.77 age at first EHR record, duration of EHR, sex, eMERGE site, first five ancestry-specific principal components
PPM001746 PSS000898 PGP000143 Fahed AC et al. (2020) Ext. Reported Trait: Coronary artery disease OR: 1.25 [1.12, 1.4] PCs(1-4)
PPM001747 PSS000902 PGP000143 Fahed AC et al. (2020) Ext. Reported Trait: Coronary artery disease OR: 1.47 [1.36, 1.59] PCs(1-4)
PPM001749 PSS000901 PGP000143 Fahed AC et al. (2020) Ext. Reported Trait: Coronary artery disease OR: 1.52 [1.43, 1.62] PCs(1-4)
PPM000747 PSS000367 PGP000090 Wang M et al. (2020) Ext. Reported Trait: Coronary artery disease OR: 1.5302 AUROC: 0.8021 age, sex, top 5 genetic PCs
PPM000748 PSS000365 PGP000090 Wang M et al. (2020) Ext. Reported Trait: Myocardial infarction (first-ever) OR: 1.4605 AUROC: 0.6482 age, sex, top 5 genetic PCs
PPM000749 PSS000366 PGP000090 Wang M et al. (2020) Ext. Reported Trait: Coronary artery disease OR: 1.5793 AUROC: 0.7066 age, sex, top 5 genetic PCs
PPM001617 PSS000839 PGP000129 Mosley JD et al. (2020) Ext. Reported Trait: Prevalent and incident coronary heart disease OR: 1.89 [1.75, 2.03] Age, sex, PCs (1-5)
PPM001618 PSS000837 PGP000129 Mosley JD et al. (2020) Ext. Reported Trait: Incident coronary heart disease (10-year risk) HR: 1.24 [1.15, 1.34] C-index: 0.669 [0.644, 0.691] Age, sex, PCs (1-5)
PPM001619 PSS000838 PGP000129 Mosley JD et al. (2020) Ext. Reported Trait: Incident coronary heart disease (10-year risk) HR: 1.38 [1.21, 1.58] C-index: 0.672 [0.627, 0.705] Age, sex, PCs (1-5)
PPM001621 PSS000838 PGP000129 Mosley JD et al. (2020) Ext. Reported Trait: Incident coronary heart disease (10-year risk) C-index: 0.681 [0.637, 0.715] Δ C-index (PRS+covariates vs. covariates alone): 0.021 [-0.0004, 0.043] Pooled cohort risk percentile, age, sex, PCs (1-5)
PPM001622 PSS000837 PGP000129 Mosley JD et al. (2020) Ext. Reported Trait: Incident coronary heart disease (10-year risk) C-index: 0.549 [0.521, 0.571] PCs (1-5)
PPM001623 PSS000838 PGP000129 Mosley JD et al. (2020) Ext. Reported Trait: Incident coronary heart disease (10-year risk) C-index: 0.587 [0.532, 0.623] PCs (1-5)
PPM001745 PSS000900 PGP000143 Fahed AC et al. (2020) Ext. Reported Trait: Coronary artery disease OR: 1.6 [1.44, 1.78] PCs(1-4)
PPM001748 PSS000899 PGP000143 Fahed AC et al. (2020) Ext. Reported Trait: Coronary artery disease OR: 1.66 [1.47, 1.86] PCs(1-4)

Evaluated Samples

PGS Sample Set ID
(PSS ID)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000365 Case-control study of first-onset acute myocardial infarction 244 individuals,
90.2 % Male samples
Mean = 33.0 years
Iqr = [30.0, 35.0] years
South Asian BRAVE
PSS000366 Cases composed of men and women diagnosed with coronary artery disease. Controls were selected from consenting men and women without any form of heart disease.
[
  • 1,800 cases
]
,
90.2 % Male samples
Mean = 54.0 years
Iqr = [46.0, 60.0] years
South Asian MedGenome
PSS000366 Cases composed of men and women diagnosed with coronary artery disease. Controls were selected from consenting men and women without any form of heart disease. 1,163 individuals,
76.4 % Male samples
Mean = 55.0 years
Iqr = [49.0, 62.0] years
South Asian MedGenome
PSS000367 Ascertainment of coronary artery disease was based on self-report or hospital admission diagnosis. This included individuals with ICD-9 codes of 410.X, 411.0, 412.X, or 429.79, or ICD-10 codes of I21.X, I22.X, I23.X, I24.1, or I25.2 in hospitalization records. Coronary revascularization was assessed based on an OPCS-4 coded procedure for coronary artery bypass grafting (K40.1–40.4, K41.1–41.4, or K45.1–45.5), or coronary angioplasty with or without stenting (K49.1–49.2, K49.8–49.9, K50.2, K75.1–75.4, or K75.8–75.9).
[
  • 398 cases
]
,
86.7 % Male samples
Mean = 60.6 years
Iqr = [54.4, 66.1] years
South Asian UKB
PSS000367 Ascertainment of coronary artery disease was based on self-report or hospital admission diagnosis. This included individuals with ICD-9 codes of 410.X, 411.0, 412.X, or 429.79, or ICD-10 codes of I21.X, I22.X, I23.X, I24.1, or I25.2 in hospitalization records. Coronary revascularization was assessed based on an OPCS-4 coded procedure for coronary artery bypass grafting (K40.1–40.4, K41.1–41.4, or K45.1–45.5), or coronary angioplasty with or without stenting (K49.1–49.2, K49.8–49.9, K50.2, K75.1–75.4, or K75.8–75.9). 6,846 individuals,
52.1 % Male samples
Mean = 52.8 years
Iqr = [46.3, 60.2] years
South Asian UKB
PSS000898 Coronary artery disease was defined as myocardial infarction and/or history of coronary revascularization.
[
  • 1,370 cases
  • , 15,385 controls
]
African unspecified BMBB, MESA, PHB, UKB, VIRGO
PSS000899 Coronary artery disease was defined as myocardial infarction and/or history of coronary revascularization.
[
  • 435 cases
  • , 3,553 controls
]
East Asian TaiChi, UKB
PSS000900 Coronary artery disease was defined as myocardial infarction and/or history of coronary revascularization.
[
  • 26,462 cases
  • , 448,036 controls
]
European BMBB, MESA, PHB, UKB, VIRGO
PSS000901 Coronary artery disease was defined as myocardial infarction and/or history of coronary revascularization.
[
  • 1,224 cases
  • , 7,861 controls
]
Hispanic or Latin American BMBB, MESA, PHB, VIRGO
PSS000902 Coronary artery disease was defined as myocardial infarction and/or history of coronary revascularization.
[
  • 874 cases
  • , 7,228 controls
]
South Asian BRAVE, UKB
PSS000837 Incident CHD cases were defined as having incident myocardial infarction (MI), fatal coronary event, or silent infarction or having undergone a revasclarization procedure. Median = 15.5 years
[
  • 696 cases
  • , 4,151 controls
]
,
43.6 % Male samples
Mean = 62.9 years European ARIC
PSS000838 Incident CHD cases were defined as MI, resuscitated cardiac arrest, definite or probable angina if followed by a revascularization, and CHD dead occuring by visit 5. Median = 14.2 years
[
  • 227 cases
  • , 2,163 controls
]
,
47.8 % Male samples
Mean = 61.8 years European MESA
PSS000839 Incident CHD cases were defined as having incident myocardial infarction (MI), fatal coronary event, or silent infarction or having undergone a revasclarization procedure. Prevalent CHD cases were participants with a reported history of MI, heart or arterial surgery, coronary artery bypass graft surgery, or angioplasty; or evidence of having had an MI based on electrocardiogram taken at their visit 1 examination.
[
  • 1,005 cases
  • , 3,842 controls
]
,
43.6 % Male samples
Mean = 62.9 years European ARIC
PSS000467 Individuals were free of CAD at time of enrollment. CAD was defined as (1)fatal or nonfatal myocardial infarction: defined based on either International Classification of Diseases, Ninth Revision (ICD-9) code 410 or Tenth Revision (ICD-10) code I21, (2)coronary artery bypass graft surgery: defined as procedure codes 3065, 3066, 3068, 3080, 3092, 3105, 3127 or 3158 (the Op6 system) or procedure code FN (the KKA97 system), (3)percutaneous coronary intervention, (4)death due to CAD: defined as ICD-9 codes 412 and 414 or ICD-10 codes I22, I23 and I25. Median = 21.3 years
Iqr = [16.1, 23.1] years
[
  • 4,122 cases
  • , 24,434 controls
]
,
38.7 % Male samples
Mean = 57.9 years European, NR European=28286, NR=270 MDC
PSS000468 Individuals were free of CAD at time of enrollment. CAD was defined as (1)fatal or nonfatal myocardial infarction: defined based on either International Classification of Diseases, Ninth Revision (ICD-9) code 410 or Tenth Revision (ICD-10) code I21, (2)coronary artery bypass graft surgery: defined as procedure codes 3065, 3066, 3068, 3080, 3092, 3105, 3127 or 3158 (the Op6 system) or procedure code FN (the KKA97 system), (3)percutaneous coronary intervention, (4)death due to CAD: defined as ICD-9 codes 412 and 414 or ICD-10 codes I22, I23 and I25. All individuals included had measured cholesterol concentrations. Median = 23.2 years
Iqr = [17.6, 24.2] years
[
  • 815 cases
  • , 4,870 controls
]
,
41.16 % Male samples
European, NR European=5640, NR=45 MDC-CC Cardiovascular Cohort
PSS000469 Individuals were free of CAD at time of enrollment. CAD was defined based on hospitalisation with or death due to ICD-10 codes for acute or subsequent myocaridal infarction (I21, I22, I23, I24.1, and I25.2); or hospitalisation with ICD-9 codes for myocaridal. infarction (410, 411, and 412); or hospitalisation with OPCS-4 (Office of Population Censuses and Surveys) codes. for coronary artery bypass grafting (K40, K41, and K45) or coronary angioplasty with or without stenting (K49, K50.2, and K75). Median = 8.1 years
Iqr = [7.4, 8.8] years
[
  • 7,708 cases
  • , 317,295 controls
]
,
44.2 % Male samples
Mean = 56.8 years European, African unspecified, South Asian, East Asian, NR European=304270, African unspecified=5760, South Asian=6832, East Asian (Chinese)=1117, NR=7024 UKB
PSS000514 ICD-9 diagnosis code for acute myocardial infarction, other acute/subacute forms of ischemic heart disease, old myocardial infarction, other forms of chronic ischemic heart disease, certain unspecified sequelae of myocardial infarction, coronary bypass, or coronary revascularization (36.1, 36.2, 410, 411, 412, 414, 429.7); ICD-10 diagnosis code for acute myocardial infarction, subsequent myocardial infarction, complications following myocardial infarction, other acute ischemic heart disease, or chronic ischemic heart disease (I21, I22, I23, I24, I25); CPT procedure code for coronary artery bypass, percutaneous transluminal angioplasty/revascularization/thrombectomy, or coronary thrombolysis (3351x, 3353x, 9292x, 9293x, 9294x, 9297x)
[
  • 2,824 cases
  • , 21,547 controls
]
,
42.7 % Male samples
Mean = 57.0 years European, Hispanic or Latin American, African unspecified African unspecified=6979, European=10344, Hispanic or Latin American=7048 Mount Sinai
PSS000515 ICD-9 diagnosis code for acute myocardial infarction, other acute/subacute forms of ischemic heart disease, old myocardial infarction, other forms of chronic ischemic heart disease, certain unspecified sequelae of myocardial infarction, coronary bypass, or coronary revascularization (36.1, 36.2, 410, 411, 412, 414, 429.7); ICD-10 diagnosis code for acute myocardial infarction, subsequent myocardial infarction, complications following myocardial infarction, other acute ischemic heart disease, or chronic ischemic heart disease (I21, I22, I23, I24, I25); CPT procedure code for coronary artery bypass, percutaneous transluminal angioplasty/revascularization/thrombectomy, or coronary thrombolysis (3351x, 3353x, 9292x, 9293x, 9294x, 9297x) 6,979 individuals African unspecified Mount Sinai
PSS000516 ICD-9 diagnosis code for acute myocardial infarction, other acute/subacute forms of ischemic heart disease, old myocardial infarction, other forms of chronic ischemic heart disease, certain unspecified sequelae of myocardial infarction, coronary bypass, or coronary revascularization (36.1, 36.2, 410, 411, 412, 414, 429.7); ICD-10 diagnosis code for acute myocardial infarction, subsequent myocardial infarction, complications following myocardial infarction, other acute ischemic heart disease, or chronic ischemic heart disease (I21, I22, I23, I24, I25); CPT procedure code for coronary artery bypass, percutaneous transluminal angioplasty/revascularization/thrombectomy, or coronary thrombolysis (3351x, 3353x, 9292x, 9293x, 9294x, 9297x) 10,344 individuals European Mount Sinai
PSS000517 ICD-9 diagnosis code for acute myocardial infarction, other acute/subacute forms of ischemic heart disease, old myocardial infarction, other forms of chronic ischemic heart disease, certain unspecified sequelae of myocardial infarction, coronary bypass, or coronary revascularization (36.1, 36.2, 410, 411, 412, 414, 429.7); ICD-10 diagnosis code for acute myocardial infarction, subsequent myocardial infarction, complications following myocardial infarction, other acute ischemic heart disease, or chronic ischemic heart disease (I21, I22, I23, I24, I25); CPT procedure code for coronary artery bypass, percutaneous transluminal angioplasty/revascularization/thrombectomy, or coronary thrombolysis (3351x, 3353x, 9292x, 9293x, 9294x, 9297x) 7,048 individuals Hispanic or Latin American Mount Sinai
PSS000518 ICD-9 diagnosis code for acute myocardial infarction, other acute/subacute forms of ischemic heart disease, old myocardial infarction, other forms of chronic ischemic heart disease, certain unspecified sequelae of myocardial infarction, coronary bypass, or coronary revascularization (36.1, 36.2, 410, 411, 412, 414, 429.7); ICD-10 diagnosis code for acute myocardial infarction, subsequent myocardial infarction, complications following myocardial infarction, other acute ischemic heart disease, or chronic ischemic heart disease (I21, I22, I23, I24, I25); CPT procedure code for coronary artery bypass, percutaneous transluminal angioplasty/revascularization/thrombectomy, or coronary thrombolysis (3351x, 3353x, 9292x, 9293x, 9294x, 9297x)
[
  • 3,538 cases
  • , 10,129 controls
]
,
45.0 % Male samples
Mean = 60.0 years European, African unspecified, Hispanic or Latin American, East Asian, South Asian African unspecified=867, East Asian=167, European=11725, Hispanic or Latin American=799, South Asian=109 PHB
PSS000519 ICD-9 diagnosis code for acute myocardial infarction, other acute/subacute forms of ischemic heart disease, old myocardial infarction, other forms of chronic ischemic heart disease, certain unspecified sequelae of myocardial infarction, coronary bypass, or coronary revascularization (36.1, 36.2, 410, 411, 412, 414, 429.7); ICD-10 diagnosis code for acute myocardial infarction, subsequent myocardial infarction, complications following myocardial infarction, other acute ischemic heart disease, or chronic ischemic heart disease (I21, I22, I23, I24, I25); CPT procedure code for coronary artery bypass, percutaneous transluminal angioplasty/revascularization/thrombectomy, or coronary thrombolysis (3351x, 3353x, 9292x, 9293x, 9294x, 9297x)
[
  • 4,658 cases
  • , 4,412 controls
]
,
59.0 % Male samples
Mean = 68.0 years European, African unspecified African unspecified=1927, European=7143 PMB
PSS000520 ICD-9 diagnosis code for acute myocardial infarction, other acute/subacute forms of ischemic heart disease, old myocardial infarction, other forms of chronic ischemic heart disease, certain unspecified sequelae of myocardial infarction, coronary bypass, or coronary revascularization (36.1, 36.2, 410, 411, 412, 414, 429.7); ICD-10 diagnosis code for acute myocardial infarction, subsequent myocardial infarction, complications following myocardial infarction, other acute ischemic heart disease, or chronic ischemic heart disease (I21, I22, I23, I24, I25); CPT procedure code for coronary artery bypass, percutaneous transluminal angioplasty/revascularization/thrombectomy, or coronary thrombolysis (3351x, 3353x, 9292x, 9293x, 9294x, 9297x)
[
  • 11,020 cases
  • , 36,088 controls
]
,
46.52 % Male samples
Mean = 59.6 years European, African unspecified, Hispanic or Latin America, East Asian, South Asian African unspecified=9773, East Asian=167, European=29212, Hispanic or Latin America=7847, South Asian=109 Mount Sinai, PHB, PMB
PSS000219 Phenotypic information was self-reported by the individual through an online, interactive health history tool
[
  • 126 cases
  • , 10,884 controls
]
,
17.1 % Male samples
European CG Samples are individuals whose healthcare provider had ordered a Color Genomics multi-gene panel test
PSS000227
[
  • 40 cases
  • , 504 controls
]
Asian unspecified MESA, VIRGO Cases are from VIRGO, controls are from MESA
PSS000228
[
  • 336 cases
  • , 962 controls
]
African American or Afro-Caribbean MESA, VIRGO Cases are from VIRGO, controls are from MESA
PSS000229
[
  • 168 cases
  • , 751 controls
]
Hispanic or Latin American MESA, VIRGO Cases are from VIRGO, controls are from MESA
PSS000230
[
  • 1,537 cases
  • , 1,544 controls
]
European MESA, VIRGO Cases are from VIRGO, controls are from MESA
PSS000015 CAD ascertainment was based on a composite of myocardial infarction or coronary revascularization. Myocardial infarction was based on self-report or hospital admission diagnosis, as performed centrally. This included individuals with ICD-9 codes of 410.X, 411.0, 412.X, or 429.79, or ICD-10 codes of I21.X, I22.X, I23.X, I24.1, or I25.2 in hospitalization records. Coronary revascularization was assessed based on an OPCS-4 coded procedure for coronary artery bypass grafting (K40.1–40.4, K41.1–41.4, or K45.1–45.5), or coronary angioplasty with or without stenting (K49.1–49.2, K49.8–49.9, K50.2, K75.1–75.4, or K75.8–75.9).
[
  • 8,676 cases
  • , 280,302 controls
]
European UKB UKB Phase 2
PSS000019 Prevalent Coronary artery disease (CAD), where CAD is defined as previous diagnosis of myocardial infarction or revascularization procedures (percutaneous coronary intervention or coronary artery bypass grafting).
[
  • 173 cases
  • , 5,589 controls
]
,
41.29 % Male samples
European
(French Canadian)
CARTaGENE
PSS000020 Recurrent CAD event during the follow- up period (median follow-up time =3.9 years [range =1.1–7), where CAD is defined as previous diagnosis of myocardial infarction or revascularization procedures (percutaneous coronary intervention or coronary artery bypass grafting).
[
  • 446 cases
  • , 416 controls
]
European
(French Canadian)
MHI Phase 1
PSS000020 Recurrent CAD event during the follow- up period (median follow-up time =3.9 years [range =1.1–7), where CAD is defined as previous diagnosis of myocardial infarction or revascularization procedures (percutaneous coronary intervention or coronary artery bypass grafting).
[
  • 937 cases
  • , 1,396 controls
]
European
(French Canadian)
MHI Phase 2
PSS000021 Prevalent Coronary artery disease (CAD), where CAD is defined as previous diagnosis of myocardial infarction or revascularization procedures (percutaneous coronary intervention or coronary artery bypass grafting).
[
  • 974 cases
  • , 976 controls
]
,
72.7 % Male samples
European
(French Canadian)
MHI Phase 1
PSS000022 Prevalent Coronary artery disease (CAD), where CAD is defined as previous diagnosis of myocardial infarction or revascularization procedures (percutaneous coronary intervention or coronary artery bypass grafting).
[
  • 2,492 cases
  • , 817 controls
]
,
72.38 % Male samples
European
(French Canadian)
MHI Phase 2
PSS000331 CHD was defined as occurrence of either myocardial infarction (MI) or coronary revascularization events (such as percutaneous coronary intervention or coronary artery bypass grafting) using ICD codes. Individuals with MI were defined as those whose EHR included at least two related diagnostic codes on separate occasions within a 5-day window, and individuals with coronary revascularization were defined as those who had at least one relevant procedural code in the EHR. ICD codelists and phenotyping algorithm in PMID:27678441 and PMID:25717410 Median = 9.2 years
Iqr = [5.5, 13.0] years
[
  • 838 cases
  • , 6,759 controls
]
,
31.0 % Male samples
Mean = 43.6 years
Sd = 12.5 years
African American or Afro-Caribbean 7 cohorts
  • BioVu
  • ,Columbia
  • ,KP
  • ,Mount Sinai
  • ,Nugene
  • ,PHB
  • ,eMERGE
right censored at age 75 years or at the age of last observation (whichever was first)
PSS000332 CHD was defined as occurrence of either myocardial infarction (MI) or coronary revascularization events (such as percutaneous coronary intervention or coronary artery bypass grafting) using ICD codes. Individuals with MI were defined as those whose EHR included at least two related diagnostic codes on separate occasions within a 5-day window, and individuals with coronary revascularization were defined as those who had at least one relevant procedural code in the EHR. We identified the first CHD event and classified it as ‘‘incident’’ if the event occurred at least 6 months after the participant’s first record in the EHR and if there were no previous ICD-9-CM or ICD-10-CM codes associated with CHD. ICD codelists and phenotyping algorithm in PMID:27678441 and PMID:25717410 Median = 9.2 years
Iqr = [5.5, 13.0] years
[
  • 311 cases
  • , 6,759 controls
]
,
31.0 % Male samples
Mean = 43.6 years
Sd = 12.5 years
African American or Afro-Caribbean 7 cohorts
  • BioVu
  • ,Columbia
  • ,KP
  • ,Mount Sinai
  • ,Nugene
  • ,PHB
  • ,eMERGE
right censored at age 75 years or at the age of last observation (whichever was first)
PSS000333 CHD was defined as occurrence of either myocardial infarction (MI) or coronary revascularization events (such as percutaneous coronary intervention or coronary artery bypass grafting) using ICD codes. Individuals with MI were defined as those whose EHR included at least two related diagnostic codes on separate occasions within a 5-day window, and individuals with coronary revascularization were defined as those who had at least one relevant procedural code in the EHR. ICD codelists and phenotyping algorithm in PMID:27678441 and PMID:25717410 Median = 11.7 years
Iqr = [6.0, 18.5] years
[
  • 8,108 cases
  • , 37,537 controls
]
,
44.6 % Male samples
Mean = 49.0 years
Sd = 14.1 years
European 11 cohorts
  • BioVu
  • ,CCHMC
  • ,Columbia
  • ,KP
  • ,MAYO
  • ,Marshfield
  • ,Mount Sinai
  • ,MyCode
  • ,Nugene
  • ,PHB
  • ,eMERGE
right censored at age 75 years or at the age of last observation (whichever was first)
PSS000334 CHD was defined as occurrence of either myocardial infarction (MI) or coronary revascularization events (such as percutaneous coronary intervention or coronary artery bypass grafting) using ICD codes. Individuals with MI were defined as those whose EHR included at least two related diagnostic codes on separate occasions within a 5-day window, and individuals with coronary revascularization were defined as those who had at least one relevant procedural code in the EHR. We identified the first CHD event and classified it as ‘‘incident’’ if the event occurred at least 6 months after the participant’s first record in the EHR and if there were no previous ICD-9-CM or ICD-10-CM codes associated with CHD. ICD codelists and phenotyping algorithm in PMID:27678441 and PMID:25717410 Median = 11.7 years
Iqr = [6.0, 18.5] years
[
  • 2,221 cases
  • , 37,537 controls
]
,
44.6 % Male samples
Mean = 49.0 years
Sd = 14.1 years
European 11 cohorts
  • BioVu
  • ,CCHMC
  • ,Columbia
  • ,KP
  • ,MAYO
  • ,Marshfield
  • ,Mount Sinai
  • ,MyCode
  • ,Nugene
  • ,PHB
  • ,eMERGE
right censored at age 75 years or at the age of last observation (whichever was first)
PSS000335 CHD was defined as occurrence of either myocardial infarction (MI) or coronary revascularization events (such as percutaneous coronary intervention or coronary artery bypass grafting) using ICD codes. Individuals with MI were defined as those whose EHR included at least two related diagnostic codes on separate occasions within a 5-day window, and individuals with coronary revascularization were defined as those who had at least one relevant procedural code in the EHR. ICD codelists and phenotyping algorithm in PMID:27678441 and PMID:25717410 Median = 10.4 years
Iqr = [5.7, 14.7] years
[
  • 419 cases
  • , 2,074 controls
]
,
36.2 % Male samples
Mean = 41.1 years
Sd = 13.2 years
Hispanic or Latin American 8 cohorts
  • BioVu
  • ,Columbia
  • ,KP
  • ,MAYO
  • ,Mount Sinai
  • ,Nugene
  • ,PHB
  • ,eMERGE
right censored at age 75 years or at the age of last observation (whichever was first)
PSS000336 CHD was defined as occurrence of either myocardial infarction (MI) or coronary revascularization events (such as percutaneous coronary intervention or coronary artery bypass grafting) using ICD codes. Individuals with MI were defined as those whose EHR included at least two related diagnostic codes on separate occasions within a 5-day window, and individuals with coronary revascularization were defined as those who had at least one relevant procedural code in the EHR. We identified the first CHD event and classified it as ‘‘incident’’ if the event occurred at least 6 months after the participant’s first record in the EHR and if there were no previous ICD-9-CM or ICD-10-CM codes associated with CHD. ICD codelists and phenotyping algorithm in PMID:27678441 and PMID:25717410 Median = 10.4 years
Iqr = [5.7, 14.7] years
[
  • 120 cases
  • , 2,074 controls
]
,
36.2 % Male samples
Mean = 41.1 years
Sd = 13.2 years
Hispanic or Latin American 8 cohorts
  • BioVu
  • ,Columbia
  • ,KP
  • ,MAYO
  • ,Mount Sinai
  • ,Nugene
  • ,PHB
  • ,eMERGE
right censored at age 75 years or at the age of last observation (whichever was first)
PSS000365 Case-control study of first-onset acute myocardial infarction
[
  • 247 cases
]
,
90.7 % Male samples
Mean = 34.0 years
Iqr = [30.0, 35.0] years
South Asian BRAVE