Polygenic Score (PGS) ID: PGS000151

Predicted Trait
Reported Trait Colorectal cancer
Mapped Trait(s) colorectal cancer (MONDO_0005575)
Released in PGS Catalog: April 29, 2020
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Score Details

Score Construction
PGS Name SC_GRS
Development Method
Name Genome-wide significant variants
Parameters Unweighted sum of risk alleles; r2 threshold = 0.8; MAF > 0.05; p-value < 5e-8 in Asian or European population
Variants
Original Genome Build GRCh37
Number of Variants 14
Effect Weight Type Unweighted
PGS Source
PGS Catalog Publication (PGP) ID PGP000074
Citation (link to publication) Xin J et al. Gene (2018)
Ancestry Distribution
PGS Evaluation
East Asian: 100%
1 Sample Sets

Development Samples

No sample information available.

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM000471 PSS000271|
East Asian Ancestry|
3,523 individuals
 PGP000074 |
Xin J et al. Gene (2018)
 Reported Trait: Colorectal cancer — AUROC: 0.607 [0.581, 0.633] — smoking status —
PPM000470 PSS000271|
East Asian Ancestry|
3,523 individuals
 PGP000074 |
Xin J et al. Gene (2018)
 Reported Trait: Colorectal cancer — AUROC: 0.6 [0.579, 0.622] — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000271 — —
[
  • 1,316 cases
  • , 2,207 controls
]
,
40.85 % Male samples
 Mean (Cases) = 58.34 years
Sd (Cases) = 12.85 years		 East Asian
(Han Chinese)		 — NCRCC —