Polygenic Score (PGS) ID: PGS000151

Predicted Trait
Reported Trait Colorectal cancer
Mapped Trait(s) colorectal cancer (EFO_0005842)
Released in PGS: April 29, 2020

Score Details

Score Construction
Original Genome Build GRCh37
Number of Variants 14
Development Method
Name GWAS-significant variants
Parameters Unweighted sum of risk alleles; r2 threshold = 0.8; MAF > 0.05; p-value < 5e-8 in Asian or European population
PGS Source
PGS Catalog Publication (PGP) ID PGP000074
Citation (link to publication) Xin J et al. Gene (2018)

Contributing Samples

No sample information available.

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID
PGS Sample Set ID
Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in the Model PGS Performance: Other Relevant Information
PPM000470 PSS000271 PGP000074
Xin J et al. (2018)
Reported Trait: Colorectal cancer AUROC: 0.6[0.579, 0.622]
PPM000471 PSS000271 PGP000074
Xin J et al. (2018)
Reported Trait: Colorectal cancer AUROC: 0.607[0.581, 0.633] smoking status

Evaluated Samples

PGS Sample Set ID
Detailed Phenotype Description Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
  • 1,316 cases
  • , 2,207 controls
40.85 % Male samples
Mean (Cases) = 58.34 years
Sd (Cases) = 12.85 years
East Asian
(Han Chinese)