Polygenic Score (PGS) ID: PGS003429

Predicted Trait
Reported Trait Abdominal aortic aneurysm
Mapped Trait(s) Abdominal Aortic Aneurysm (EFO_0004214)
Released in PGS Catalog: Dec. 15, 2023
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Score Details

Score Construction
PGS Name AAA
Development Method
Name shaPRS + LDpred2
Parameters auto option (for both shaPRS and LDpred2)
Variants
Original Genome Build GRCh37
Number of Variants 831,447
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000436
Citation (link to publication) Kelemen M K et al. medRxiv (2023) Preprint
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 88.6%
Multi-ancestry (including European): 11.4%
  • European
  • Not Reported
556,900 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
Europe PMC: 25826379
[
  • 1,068 cases
  • , 127,011 controls
]
 European
(U.K.)		 UKB
Europe PMC: 25826379
[
  • 133,900 cases
  • , 127,011 controls
]
 European
(U.K.)		 UKB
— 104,179 individuals European NR
GWAS Catalog: GCST004787
Europe PMC: 28714975
[
  • 18,467 cases
  • , 45,264 controls
]
 European, NR NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM017103 PSS010126|
European Ancestry|
91,731 individuals
 PGP000436 |
Kelemen M K et al. medRxiv (2023)
|Pre		 Reported Trait: Abdominal aortic aneurysm — AUROC: 0.708 [0.691, 0.725] R²: 0.00547 — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS010126 — —
[
  • 921 cases
  • , 90,810 controls
]
 — European
(U.K.)		 — UKB —