PGS Preprint: PGP000436

Publication Information (EuropePMC)
Title Evaluating the cost-effectiveness of polygenic risk score-stratified screening for abdominal aortic aneurysm
doi 10.1101/2023.11.02.23297906
Publication Date Feb. 20, 2023
Journal medRxiv Preprint
Author(s) Kelemen M, Roychowdhury T, Danesh J, Di Angelantonio E, Inouye M, O’Sullivan J, Pennells L, Sweeting M, Wood A, Harrison S, Kim L.
Released in PGS Catalog: Dec. 15, 2023

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS003429
(AAA)
 PGP000436 |
Kelemen M K et al. medRxiv (2023)
|Pre		 Abdominal aortic aneurysm Abdominal Aortic Aneurysm 831,447
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003429/ScoringFiles/PGS003429.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM017103 PGS003429
(AAA)
 PSS010126|
European Ancestry|
91,731 individuals
 PGP000436 |
Kelemen M K et al. medRxiv (2023)
|Pre		 Reported Trait: Abdominal aortic aneurysm — AUROC: 0.708 [0.691, 0.725] R²: 0.00547 — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS010126 — —
[
  • 921 cases
  • , 90,810 controls
]
 — European
(U.K.)		 — UKB —