Polygenic Score (PGS) ID: PGS003763

Predicted Trait
Reported Trait Parkinson's disease
Mapped Trait(s) Parkinson disease (MONDO_0005180)
Released in PGS Catalog: Aug. 4, 2023
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Score Details

Score Construction
PGS Name PRS44_PD
Development Method
Name Genome-wide significant SNPs
Parameters NR
Variants
Original Genome Build NR
Number of Variants 44
Effect Weight Type log(OR)
PGS Source
PGS Catalog Publication (PGP) ID PGP000486
Citation (link to publication) Zheng Z et al. JAMA Neurol (2023)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
417,508 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST004902
Europe PMC: 28892059
 417,508 individuals European NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM018563 PSS011026|
European Ancestry|
314,998 individuals
 PGP000486 |
Zheng Z et al. JAMA Neurol (2023)
 Reported Trait: Incident Parkinson Disease — — Hazard ratio (HR, high vs low tertile): 1.72 [1.54, 1.93] genotyping array and the first 10 principal components of ancestry —
PPM018564 PSS011026|
European Ancestry|
314,998 individuals
 PGP000486 |
Zheng Z et al. JAMA Neurol (2023)
 Reported Trait: Incident Parkinson Disease with frailty — — Hazard ratio (HR, high vs low tertile): 3.22 [2.35, 4.41] age, sex, Townsend deprivation index, assessment centers, alcohol consumption, smoking status, BMI, the number of long-term morbidities, genotyping array, and the first 10 principal components of ancestry long-term morbidities, genotyping array, and the first 10 principal components of ancestry —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011026 — — 314,998 individuals,
49.1 % Male samples
 Mean = 56.1 years European — UKB —