PGS Publication: PGP000486

Publication Information (EuropePMC)
Title Physical Frailty, Genetic Predisposition, and Incident Parkinson Disease.
PubMed ID 36912851(Europe PMC)
doi 10.1001/jamaneurol.2023.0183
Publication Date May 1, 2023
Journal JAMA Neurol
Author(s) Zheng Z, Lv Y, Rong S, Sun T, Chen L.
Released in PGS Catalog: Aug. 4, 2023

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS003763
(PRS44_PD)
 PGP000486 |
Zheng Z et al. JAMA Neurol (2023)
 Parkinson's disease Parkinson disease 44
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003763/ScoringFiles/PGS003763.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM018563 PGS003763
(PRS44_PD)
 PSS011026|
European Ancestry|
314,998 individuals
 PGP000486 |
Zheng Z et al. JAMA Neurol (2023)
 Reported Trait: Incident Parkinson Disease — — Hazard ratio (HR, high vs low tertile): 1.72 [1.54, 1.93] genotyping array and the first 10 principal components of ancestry —
PPM018564 PGS003763
(PRS44_PD)
 PSS011026|
European Ancestry|
314,998 individuals
 PGP000486 |
Zheng Z et al. JAMA Neurol (2023)
 Reported Trait: Incident Parkinson Disease with frailty — — Hazard ratio (HR, high vs low tertile): 3.22 [2.35, 4.41] age, sex, Townsend deprivation index, assessment centers, alcohol consumption, smoking status, BMI, the number of long-term morbidities, genotyping array, and the first 10 principal components of ancestry long-term morbidities, genotyping array, and the first 10 principal components of ancestry —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011026 — — 314,998 individuals,
49.1 % Male samples
 Mean = 56.1 years European — UKB —