Polygenic Score (PGS) ID: PGS003959

Predicted Trait
Reported Trait Obesity
Mapped Trait(s) obesity (EFO_0001073)
Released in PGS Catalog: Oct. 17, 2023
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Score Details

Score Construction
PGS Name GRS940_obesity
Development Method
Name Genome-wide significant SNPs
Parameters NR
Variants
Original Genome Build NR
Number of Variants 940
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000507
Citation (link to publication) Liu X et al. Clin Nutr (2023)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 67%
Not Reported: 33%
681,275 individuals (100%)
PGS Evaluation
Multi-ancestry (including European): 100%
  • European
  • Not Reported
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST006900
Europe PMC: 30124842
 224,849 individuals NR NR
GWAS Catalog: GCST006900
Europe PMC: 30124842
 456,426 individuals European NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM019108 PSS011184|
Multi-ancestry (including European)|
27,429 individuals
 PGP000507 |
Liu X et al. Clin Nutr (2023)
 Reported Trait: Abdominal obesity β: 0.078 (0.019) — — Age, sex, race, centres, education, Townsend deprivation index, household income, smoking, alcohol consumption, physical activity, sleep pattern, energy intake, and BMI, WC or BF% at baseline —
PPM019109 PSS011184|
Multi-ancestry (including European)|
27,429 individuals
 PGP000507 |
Liu X et al. Clin Nutr (2023)
 Reported Trait: Body mass index increase β: 0.157 (0.013) — — Age, sex, race, centres, education, Townsend deprivation index, household income, smoking, alcohol consumption, physical activity, sleep pattern, energy intake, and BMI, WC or BF% at baseline —
PPM019110 PSS011184|
Multi-ancestry (including European)|
27,429 individuals
 PGP000507 |
Liu X et al. Clin Nutr (2023)
 Reported Trait: Wasit circumference increase β: 0.213 (0.039) — — Age, sex, race, centres, education, Townsend deprivation index, household income, smoking, alcohol consumption, physical activity, sleep pattern, energy intake, and BMI, WC or BF% at baseline —
PPM019111 PSS011184|
Multi-ancestry (including European)|
27,429 individuals
 PGP000507 |
Liu X et al. Clin Nutr (2023)
 Reported Trait: Body fat percentage increase β: 0.042 (0.021) — — Age, sex, race, centres, education, Townsend deprivation index, household income, smoking, alcohol consumption, physical activity, sleep pattern, energy intake, and BMI, WC or BF% at baseline —
PPM019112 PSS011184|
Multi-ancestry (including European)|
27,429 individuals
 PGP000507 |
Liu X et al. Clin Nutr (2023)
 Reported Trait: Obesity with sulfur microbial diet score — — Hazard ratio (HR, Q4 sulphur microbial diet score and high PRS vs. Q1 sulphur microbial diet score and low PRS): 1.74 [1.33, 2.29] age, sex, race, centers, household income, Townsend deprivation index, smoking, alcohol consumption, physical activity, sleep pattern, energy intake and body mass index or waist circumstance —
PPM019113 PSS011184|
Multi-ancestry (including European)|
27,429 individuals
 PGP000507 |
Liu X et al. Clin Nutr (2023)
 Reported Trait: Abdominal obesity with sulfur microbial diet score — — Hazard ratio (HR, Q4 sulphur microbial diet score and high PRS vs. Q1 sulphur microbial diet score and low PRS): 1.41 [1.17, 1.71] age, sex, race, centers, household income, Townsend deprivation index, smoking, alcohol consumption, physical activity, sleep pattern, energy intake and body mass index or waist circumstance —
PPM019107 PSS011184|
Multi-ancestry (including European)|
27,429 individuals
 PGP000507 |
Liu X et al. Clin Nutr (2023)
 Reported Trait: Obesity β: 0.149 (0.028) — — Age, sex, race, centres, education, Townsend deprivation index, household income, smoking, alcohol consumption, physical activity, sleep pattern, energy intake, and BMI, WC or BF% at baseline —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011184 — — 27,429 individuals,
47.0 % Male samples
 Mean = 55.3 years
Sd = 7.6 years		 European, Not reported — UKB —