PGS Publication: PGP000507

Publication Information (EuropePMC)
Title The sulfur microbial diet and increased risk of obesity: Findings from a population-based prospective cohort study.
PubMed ID 37003050(Europe PMC)
doi 10.1016/j.clnu.2023.03.011
Publication Date March 17, 2023
Journal Clin Nutr
Author(s) Liu X, Wan X, Zhang L, Li Y, Ao Y, Zhuang P, Wu Y, Zhang Y, Jiao J.
Released in PGS Catalog: Oct. 17, 2023

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS003959
(GRS940_obesity)
 PGP000507 |
Liu X et al. Clin Nutr (2023)
 Obesity obesity 940
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003959/ScoringFiles/PGS003959.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM019108 PGS003959
(GRS940_obesity)
 PSS011184|
Multi-ancestry (including European)|
27,429 individuals
 PGP000507 |
Liu X et al. Clin Nutr (2023)
 Reported Trait: Abdominal obesity β: 0.078 (0.019) — — Age, sex, race, centres, education, Townsend deprivation index, household income, smoking, alcohol consumption, physical activity, sleep pattern, energy intake, and BMI, WC or BF% at baseline —
PPM019109 PGS003959
(GRS940_obesity)
 PSS011184|
Multi-ancestry (including European)|
27,429 individuals
 PGP000507 |
Liu X et al. Clin Nutr (2023)
 Reported Trait: Body mass index increase β: 0.157 (0.013) — — Age, sex, race, centres, education, Townsend deprivation index, household income, smoking, alcohol consumption, physical activity, sleep pattern, energy intake, and BMI, WC or BF% at baseline —
PPM019110 PGS003959
(GRS940_obesity)
 PSS011184|
Multi-ancestry (including European)|
27,429 individuals
 PGP000507 |
Liu X et al. Clin Nutr (2023)
 Reported Trait: Wasit circumference increase β: 0.213 (0.039) — — Age, sex, race, centres, education, Townsend deprivation index, household income, smoking, alcohol consumption, physical activity, sleep pattern, energy intake, and BMI, WC or BF% at baseline —
PPM019111 PGS003959
(GRS940_obesity)
 PSS011184|
Multi-ancestry (including European)|
27,429 individuals
 PGP000507 |
Liu X et al. Clin Nutr (2023)
 Reported Trait: Body fat percentage increase β: 0.042 (0.021) — — Age, sex, race, centres, education, Townsend deprivation index, household income, smoking, alcohol consumption, physical activity, sleep pattern, energy intake, and BMI, WC or BF% at baseline —
PPM019112 PGS003959
(GRS940_obesity)
 PSS011184|
Multi-ancestry (including European)|
27,429 individuals
 PGP000507 |
Liu X et al. Clin Nutr (2023)
 Reported Trait: Obesity with sulfur microbial diet score — — Hazard ratio (HR, Q4 sulphur microbial diet score and high PRS vs. Q1 sulphur microbial diet score and low PRS): 1.74 [1.33, 2.29] age, sex, race, centers, household income, Townsend deprivation index, smoking, alcohol consumption, physical activity, sleep pattern, energy intake and body mass index or waist circumstance —
PPM019113 PGS003959
(GRS940_obesity)
 PSS011184|
Multi-ancestry (including European)|
27,429 individuals
 PGP000507 |
Liu X et al. Clin Nutr (2023)
 Reported Trait: Abdominal obesity with sulfur microbial diet score — — Hazard ratio (HR, Q4 sulphur microbial diet score and high PRS vs. Q1 sulphur microbial diet score and low PRS): 1.41 [1.17, 1.71] age, sex, race, centers, household income, Townsend deprivation index, smoking, alcohol consumption, physical activity, sleep pattern, energy intake and body mass index or waist circumstance —
PPM019107 PGS003959
(GRS940_obesity)
 PSS011184|
Multi-ancestry (including European)|
27,429 individuals
 PGP000507 |
Liu X et al. Clin Nutr (2023)
 Reported Trait: Obesity β: 0.149 (0.028) — — Age, sex, race, centres, education, Townsend deprivation index, household income, smoking, alcohol consumption, physical activity, sleep pattern, energy intake, and BMI, WC or BF% at baseline —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011184 — — 27,429 individuals,
47.0 % Male samples
 Mean = 55.3 years
Sd = 7.6 years		 European, Not reported — UKB —