Polygenic Score (PGS) ID: PGS004235

Predicted Trait
Reported Trait Systolic blood pressure
Mapped Trait(s) systolic blood pressure (EFO_0006335)
Released in PGS Catalog: Dec. 15, 2023
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Score Details

Score Construction
PGS Name SBP_MVP
Development Method
Name PRSice-2
Parameters R2 = 0.1, 0.2 and 0.3, CV-PRS
Variants
Original Genome Build GRCh38
Number of Variants 24,807
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000531
Citation (link to publication) Kurniansyah N et al. Nat Commun (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 70.6%
African: 19.9%
Hispanic or Latin American: 7.2%
Additional Asian Ancestries: 1.5%
Additional Diverse Ancestries: 0.8%
318,891 individuals (100%)
Score Development/Training
Hispanic or Latin American: 40.6%
African: 27.2%
European: 24.3%
Not Reported: 6.5%
Additional Asian Ancestries: 1.5%
10,314 individuals (100%)
PGS Evaluation
Multi-ancestry (including European): 100%
  • African
  • Hispanic or Latin American
  • Additional Asian Ancestries
  • European
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST007270
Europe PMC: 30578418
225,112 individuals European MVP
GWAS Catalog: GCST007270
Europe PMC: 30578418
63,490 individuals African unspecified MVP
GWAS Catalog: GCST007270
Europe PMC: 30578418
22,802 individuals Hispanic or Latin American MVP
GWAS Catalog: GCST007270
Europe PMC: 30578418
4,792 individuals Asian unspecified MVP
GWAS Catalog: GCST007270
Europe PMC: 30578418
2,695 individuals Native American MVP
Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
2,803 individuals,
33.5 % Male samples
African American or Afro-Caribbean BioMe Mean = 55.9 years
Sd = 12.5 years
151 individuals,
44.4 % Male samples
Asian unspecified BioMe Mean = 53.14 years
Sd = 13.52 years
2,506 individuals,
52.2 % Male samples
European BioMe Mean = 60.42 years
Sd = 13.96 years
4,187 individuals,
37.5 % Male samples
Hispanic or Latin American BioMe Mean = 57.72 years
Sd = 13.18 years
667 individuals,
57.9 % Male samples
Not reported BioMe Mean = 57.51 years
Sd = 13.1 years

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM020254 PSS011312|
Multi-ancestry (including European)|
39,035 individuals
PGP000531 |
Kurniansyah N et al. Nat Commun (2022)
Reported Trait: Prevelant hypertension AUROC: 0.757 [0.744, 0.771] sex, age, age2, study site, race/ethnic background, smoking status, BMI, and 11 ancestral principal components

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011312 8,822 individuals,
31.9 % Male samples
African American or Afro-Caribbean 6 cohorts
  • ARIC
  • ,CHS
  • ,GENOA
  • ,JHS
  • ,MESA
  • ,WHI
PSS011312 6,718 individuals,
38.0 % Male samples
Hispanic or Latin American 6 cohorts
  • CHS
  • ,FHS
  • ,HCHS
  • ,MESA
  • ,SOL
  • ,WHI
PSS011312 794 individuals,
37.9 % Male samples
Asian unspecified MESA, WHI
PSS011312 22,701 individuals,
27.8 % Male samples
European ARIC, CHS, FHS, MESA, WHI