PGS Publication: PGP000531

Publication Information (EuropePMC)
Title A multi-ethnic polygenic risk score is associated with hypertension prevalence and progression throughout adulthood.
PubMed ID 35729114(Europe PMC)
doi 10.1038/s41467-022-31080-2
Publication Date June 21, 2022
Journal Nat Commun
Author(s) Kurniansyah N, Goodman MO, Kelly TN, Elfassy T, Wiggins KL, Bis JC, Guo X, Palmas W, Taylor KD, Lin HJ, Haessler J, Gao Y, Shimbo D, Smith JA, Yu B, Feofanova EV, Smit RAJ, Wang Z, Hwang SJ, Liu S, Wassertheil-Smoller S, Manson JE, Lloyd-Jones DM, Rich SS, Loos RJF, Redline S, Correa A, Kooperberg C, Fornage M, Kaplan RC, Psaty BM, Rotter JI, Arnett DK, Morrison AC, Franceschini N, Levy D, NHLBI Trans-Omics in Precision Medicine (TOPMed) Consortium, Sofer T.
Released in PGS Catalog: Dec. 15, 2023

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS004233
(DBP_MVP)
 PGP000531 |
Kurniansyah N et al. Nat Commun (2022)
 Diastolic blood pressure diastolic blood pressure 149,559
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004233/ScoringFiles/PGS004233.txt.gz
PGS004235
(SBP_MVP)
 PGP000531 |
Kurniansyah N et al. Nat Commun (2022)
 Systolic blood pressure systolic blood pressure 24,807
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004235/ScoringFiles/PGS004235.txt.gz
PGS004234
(HTN_PAN-UKBB)
 PGP000531 |
Kurniansyah N et al. Nat Commun (2022)
 Hypertension hypertension 234,228
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004234/ScoringFiles/PGS004234.txt.gz
PGS004236
(HTN_Unweighted_PRSsum)
 PGP000531 |
Kurniansyah N et al. Nat Commun (2022)
 Hypertension hypertension 398,805
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004236/ScoringFiles/PGS004236.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM020253 PGS004234
(HTN_PAN-UKBB)
 PSS011312|
Multi-ancestry (including European)|
39,035 individuals
 PGP000531 |
Kurniansyah N et al. Nat Commun (2022)
 Reported Trait: Prevelant hypertension — AUROC: 0.763 [0.75, 0.775] — sex, age, age2, study site, race/ethnic background, smoking status, BMI, and 11 ancestral principal components —
PPM020254 PGS004235
(SBP_MVP)
 PSS011312|
Multi-ancestry (including European)|
39,035 individuals
 PGP000531 |
Kurniansyah N et al. Nat Commun (2022)
 Reported Trait: Prevelant hypertension — AUROC: 0.757 [0.744, 0.771] — sex, age, age2, study site, race/ethnic background, smoking status, BMI, and 11 ancestral principal components —
PPM020255 PGS004236
(HTN_Unweighted_PRSsum)
 PSS011312|
Multi-ancestry (including European)|
39,035 individuals
 PGP000531 |
Kurniansyah N et al. Nat Commun (2022)
 Reported Trait: Prevelant hypertension OR: 2.1 [1.99, 2.21] AUROC: 0.764 [0.751, 0.777] — sex, age, age2, study site, race/ethnic background, smoking status, BMI, and 11 ancestral principal components PRSsum based on selected CV-PRS (which summed the CV-PRS from the three phenotypes).
PPM020256 PGS004236
(HTN_Unweighted_PRSsum)
 PSS011312|
Multi-ancestry (including European)|
39,035 individuals
 PGP000531 |
Kurniansyah N et al. Nat Commun (2022)
 Reported Trait: New-onset hypertension (normotensive) OR: 1.72 [1.55, 1.91] AUROC: 0.656 — sex, age, age2, study site, race/ethnic background, smoking status, BMI, and 11 ancestral principal components PRSsum based on selected CV-PRS (which summed the CV-PRS from the three phenotypes).
PPM020257 PGS004236
(HTN_Unweighted_PRSsum)
 PSS011312|
Multi-ancestry (including European)|
39,035 individuals
 PGP000531 |
Kurniansyah N et al. Nat Commun (2022)
 Reported Trait: New-onset hypertension (elevated) OR: 1.48 [1.27, 1.71] AUROC: 0.582 — sex, age, age2, study site, race/ethnic background, smoking status, BMI, and 11 ancestral principal components PRSsum based on selected CV-PRS (which summed the CV-PRS from the three phenotypes).
PPM020252 PGS004233
(DBP_MVP)
 PSS011312|
Multi-ancestry (including European)|
39,035 individuals
 PGP000531 |
Kurniansyah N et al. Nat Commun (2022)
 Reported Trait: Prevelant hypertension — AUROC: 0.754 [0.741, 0.767] — sex, age, age2, study site, race/ethnic background, smoking status, BMI, and 11 ancestral principal components —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011312 — — 8,822 individuals,
31.9 % Male samples
 — African American or Afro-Caribbean — 6 cohorts
  • ARIC
  • ,CHS
  • ,GENOA
  • ,JHS
  • ,MESA
  • ,WHI
 —
PSS011312 — — 6,718 individuals,
38.0 % Male samples
 — Hispanic or Latin American — 6 cohorts
  • CHS
  • ,FHS
  • ,HCHS
  • ,MESA
  • ,SOL
  • ,WHI
 —
PSS011312 — — 794 individuals,
37.9 % Male samples
 — Asian unspecified — MESA, WHI —
PSS011312 — — 22,701 individuals,
27.8 % Male samples
 — European — ARIC, CHS, FHS, MESA, WHI —