Polygenic Score (PGS) ID: PGS004598

Predicted Trait
Reported Trait Heart failure
Mapped Trait(s) heart failure (EFO_0003144)
Released in PGS Catalog: Jan. 26, 2024
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Score Details

Score Construction
PGS Name PRS12_HF
Development Method
Name Genome-wide significant SNPs
Parameters NR
Variants
Original Genome Build NR
Number of Variants 12
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000576
Citation (link to publication) Peng H et al. Nutrients (2023)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
977,323 individuals (100%)
PGS Evaluation
Multi-ancestry (including European): 100%
  • European
  • Not Reported
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST009541
Europe PMC: 31919418
 977,323 individuals European NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM020747 PSS011390|
Multi-ancestry (including European)|
13,348 individuals
 PGP000576 |
Peng H et al. Nutrients (2023)
 Reported Trait: Incident heart failure in breast cancer survivors — — Hazard ratio (HR, top 50% vs bottom 50% of PRS): 1.4 [1.06, 1.84] Age at diagnosis of breast cancer, race, Townsend Deprivation Index, diabetes, hypertension, antihypertensive medications, insulin treatment, lipid treatments, hormone replacement therapy, menopause, surgical treatment of breast cancer, genetic testing batches, 10 PCs —
PPM020750 PSS011390|
Multi-ancestry (including European)|
13,348 individuals
 PGP000576 |
Peng H et al. Nutrients (2023)
 Reported Trait: Incident heart failure in breast cancer survivors with lifestyle — — Hazard ratio (HR, unhealthy lifestyle and PRS in top 50% vs healthy lifestyle and PRS in bottom 50%): 0.39 [0.21, 0.73] Age at diagnosis of breast cancer, race, Townsend Deprivation Index, diabetes, hypertension, antihypertensive medications, insulin treatment, lipid treatments, hormone replacement therapy, menopause, surgical treatment of breast cancer, genetic testing batches, 10 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011390 CVD ICD-10: I20-I25, I60-I64, G45 — 12,780 individuals,
0.0 % Male samples
 — European — UKB Mean age of full combined ancestry cohort = 58.8 years (sd = 7.1)
PSS011390 CVD ICD-10: I20-I25, I60-I64, G45 — 568 individuals,
0.0 % Male samples
 — Not reported — UKB Mean age of full combined ancestry cohort = 58.8 years (sd = 7.1)