PGS Publication: PGP000576

Publication Information (EuropePMC)
Title Lifestyle Factors, Genetic Risk, and Cardiovascular Disease Risk among Breast Cancer Survivors: A Prospective Cohort Study in UK Biobank.
PubMed ID 36839222(Europe PMC)
doi 10.3390/nu15040864
Publication Date Feb. 8, 2023
Journal Nutrients
Author(s) Peng H, Wang S, Wang M, Wang X, Guo H, Huang J, Wu T.
Released in PGS Catalog: Jan. 26, 2024

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS004598
(PRS12_HF)
 PGP000576 |
Peng H et al. Nutrients (2023)
 Heart failure heart failure 12
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004598/ScoringFiles/PGS004598.txt.gz
PGS004597
(PRS32_IS)
 PGP000576 |
Peng H et al. Nutrients (2023)
 Ischemic stroke Ischemic stroke 32
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004597/ScoringFiles/PGS004597.txt.gz
PGS004596
(PRS64_CHD)
 PGP000576 |
Peng H et al. Nutrients (2023)
 Coronary heart disease coronary artery disease 64
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004596/ScoringFiles/PGS004596.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM020747 PGS004598
(PRS12_HF)
 PSS011390|
Multi-ancestry (including European)|
13,348 individuals
 PGP000576 |
Peng H et al. Nutrients (2023)
 Reported Trait: Incident heart failure in breast cancer survivors — — Hazard ratio (HR, top 50% vs bottom 50% of PRS): 1.4 [1.06, 1.84] Age at diagnosis of breast cancer, race, Townsend Deprivation Index, diabetes, hypertension, antihypertensive medications, insulin treatment, lipid treatments, hormone replacement therapy, menopause, surgical treatment of breast cancer, genetic testing batches, 10 PCs —
PPM020748 PGS004596
(PRS64_CHD)
 PSS011390|
Multi-ancestry (including European)|
13,348 individuals
 PGP000576 |
Peng H et al. Nutrients (2023)
 Reported Trait: Incident coronary artery disease in breast cancer survivors — — Hazard ratio (HR, top 50% vs bottom 50% of PRS): 1.36 [1.1, 1.67] Age at diagnosis of breast cancer, race, Townsend Deprivation Index, diabetes, hypertension, antihypertensive medications, insulin treatment, lipid treatments, hormone replacement therapy, menopause, surgical treatment of breast cancer, genetic testing batches, 10 PCs —
PPM020749 PGS004597
(PRS32_IS)
 PSS011390|
Multi-ancestry (including European)|
13,348 individuals
 PGP000576 |
Peng H et al. Nutrients (2023)
 Reported Trait: Incident ischaemic stroke in breast cancer survivors — — Hazard ratio (HR, top 50% vs bottom 50% of PRS): 1.25 [0.91, 1.72] Age at diagnosis of breast cancer, race, Townsend Deprivation Index, diabetes, hypertension, antihypertensive medications, insulin treatment, lipid treatments, hormone replacement therapy, menopause, surgical treatment of breast cancer, genetic testing batches, 10 PCs —
PPM020750 PGS004598
(PRS12_HF)
 PSS011390|
Multi-ancestry (including European)|
13,348 individuals
 PGP000576 |
Peng H et al. Nutrients (2023)
 Reported Trait: Incident heart failure in breast cancer survivors with lifestyle — — Hazard ratio (HR, unhealthy lifestyle and PRS in top 50% vs healthy lifestyle and PRS in bottom 50%): 0.39 [0.21, 0.73] Age at diagnosis of breast cancer, race, Townsend Deprivation Index, diabetes, hypertension, antihypertensive medications, insulin treatment, lipid treatments, hormone replacement therapy, menopause, surgical treatment of breast cancer, genetic testing batches, 10 PCs —
PPM020751 PGS004596
(PRS64_CHD)
 PSS011390|
Multi-ancestry (including European)|
13,348 individuals
 PGP000576 |
Peng H et al. Nutrients (2023)
 Reported Trait: Incident coronary artery disease in breast cancer survivors with lifestyle — — Hazard ratio (HR, unhealthy lifestyle and PRS in top 50% vs healthy lifestyle and PRS in bottom 50%): 0.37 [0.24, 0.56] Age at diagnosis of breast cancer, race, Townsend Deprivation Index, diabetes, hypertension, antihypertensive medications, insulin treatment, lipid treatments, hormone replacement therapy, menopause, surgical treatment of breast cancer, genetic testing batches, 10 PCs —
PPM020752 PGS004597
(PRS32_IS)
 PSS011390|
Multi-ancestry (including European)|
13,348 individuals
 PGP000576 |
Peng H et al. Nutrients (2023)
 Reported Trait: Incident ischaemic stroke in breast cancer survivors with lifestyle — — Hazard ratio (HR, unhealthy lifestyle and PRS in top 50% vs healthy lifestyle and PRS in bottom 50%): 0.37 [0.15, 0.93] Age at diagnosis of breast cancer, race, Townsend Deprivation Index, diabetes, hypertension, antihypertensive medications, insulin treatment, lipid treatments, hormone replacement therapy, menopause, surgical treatment of breast cancer, genetic testing batches, 10 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011390 CVD ICD-10: I20-I25, I60-I64, G45 — 12,780 individuals,
0.0 % Male samples
 — European — UKB Mean age of full combined ancestry cohort = 58.8 years (sd = 7.1)
PSS011390 CVD ICD-10: I20-I25, I60-I64, G45 — 568 individuals,
0.0 % Male samples
 — Not reported — UKB Mean age of full combined ancestry cohort = 58.8 years (sd = 7.1)