Polygenic Score (PGS) ID: PGS005235

Predicted Trait
Reported Trait Adiposity
Mapped Trait(s) obesity (EFO_0001073)
Additional Trait Information Multivariate GWAS of 7 indicator variables relating to adiposity
Released in PGS Catalog: Oct. 6, 2025
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Score Details

Score Construction
PGS Name F4_Adiposity
Development Method
Name LDpred2-auto
Parameters Weights were calculated using the average posterior weights for the models that converged (causal variant thresholds: 30 evenly spaced values on a logarithmic scale ranging from 1E-4 to 0.9). 5,000 unrelated individuals of European ancestry from the UK Biobank were used as an LD reference panel
Variants
Original Genome Build GRCh38
Number of Variants 709,828
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000739
Citation (link to publication) Arehart CH et al. Nat Commun (2025)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
393,268 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
393,268 individuals European EGG, GIANT, UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM022667 PSS012051|
European Ancestry|
100,960 individuals
 PGP000739 |
Arehart CH et al. Nat Commun (2025)
 Reported Trait: Obesity (phecode: 278.1) OR: 1.97046 — — age, sex, batch, and the first 10 genetic principal components —
PPM022668 PSS012051|
European Ancestry|
100,960 individuals
 PGP000739 |
Arehart CH et al. Nat Commun (2025)
 Reported Trait: Substance addiction and disorders (phecode: 316) OR: 1.34533 — — BMI, age, sex, batch, and the first 10 genetic principal components —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012051 — — 25,240 individuals — European — CCPM —
PSS012051 — — 25,240 individuals — European — CCPM —
PSS012051 — — 25,240 individuals — European — CCPM —
PSS012051 — — 25,240 individuals — European — CCPM —