PGS Publication: PGP000739

Publication Information (EuropePMC)
Title Modeling the genomic architecture of adiposity and anthropometrics across the lifespan.
PubMed ID 40796553(Europe PMC)
doi 10.1038/s41467-025-62730-w
Publication Date Aug. 13, 2025
Journal Nat Commun
Author(s) Arehart CH, Lin M, Gibson RA, Colorado Center for Personalized Medicine, Raghavan S, Gignoux CR, Stanislawski MA, Grotzinger AD, Evans LM.
Released in PGS Catalog: Oct. 6, 2025

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS005232
(F1_Birth_Size)
 PGP000739 |
Arehart CH et al. Nat Commun (2025)
 Birth size birth weight 710,799
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005232/ScoringFiles/PGS005232.txt.gz
PGS005235
(F4_Adiposity)
 PGP000739 |
Arehart CH et al. Nat Commun (2025)
 Adiposity obesity 709,828
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005235/ScoringFiles/PGS005235.txt.gz
PGS005233
(F2_Abdominal_Size)
 PGP000739 |
Arehart CH et al. Nat Commun (2025)
 Abdominal size body fat distribution 710,487
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005233/ScoringFiles/PGS005233.txt.gz
PGS005234
(F3_Body_Size_and_Adipose_Distribution)
 PGP000739 |
Arehart CH et al. Nat Commun (2025)
 Body size and adipose distribution body weight,
body fat distribution		 709,193
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005234/ScoringFiles/PGS005234.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM022664 PGS005232
(F1_Birth_Size)
 PSS012051|
European Ancestry|
100,960 individuals
 PGP000739 |
Arehart CH et al. Nat Commun (2025)
 Reported Trait: Hypertension (phecode: 401) OR: 0.88765 — — age, sex, batch, and the first 10 genetic principal components —
PPM022665 PGS005233
(F2_Abdominal_Size)
 PSS012051|
European Ancestry|
100,960 individuals
 PGP000739 |
Arehart CH et al. Nat Commun (2025)
 Reported Trait: Disorders of lipoid metabolism (phecode: 272) OR: 1.1528 — — age, sex, batch, and the first 10 genetic principal components —
PPM022666 PGS005234
(F3_Body_Size_and_Adipose_Distribution)
 PSS012051|
European Ancestry|
100,960 individuals
 PGP000739 |
Arehart CH et al. Nat Commun (2025)
 Reported Trait: Atrial fibrillation (phecode: 427.21) OR: 1.16164 — — age, sex, batch, and the first 10 genetic principal components —
PPM022667 PGS005235
(F4_Adiposity)
 PSS012051|
European Ancestry|
100,960 individuals
 PGP000739 |
Arehart CH et al. Nat Commun (2025)
 Reported Trait: Obesity (phecode: 278.1) OR: 1.97046 — — age, sex, batch, and the first 10 genetic principal components —
PPM022668 PGS005235
(F4_Adiposity)
 PSS012051|
European Ancestry|
100,960 individuals
 PGP000739 |
Arehart CH et al. Nat Commun (2025)
 Reported Trait: Substance addiction and disorders (phecode: 316) OR: 1.34533 — — BMI, age, sex, batch, and the first 10 genetic principal components —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012051 — — 25,240 individuals — European — CCPM —
PSS012051 — — 25,240 individuals — European — CCPM —
PSS012051 — — 25,240 individuals — European — CCPM —
PSS012051 — — 25,240 individuals — European — CCPM —