Polygenic Score (PGS) ID: PGS005276

Predicted Trait
Reported Trait Fasting insulin adjusted for BMI
Mapped Trait(s) BMI-adjusted fasting blood insulin measurement (EFO_0008037)
Released in PGS Catalog: Nov. 10, 2025
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Score Details

Score Construction
PGS Name FI_PS_EUR
Development Method
Name PRS-CSx
Parameters UK Biobank EUR reference panel (ldblk_ukbb_eur), phi parameter equal to 1
Variants
Original Genome Build GRCh37
Number of Variants 1,116,555
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000750
Citation (link to publication) Sarnowski C et al. Commun Biol (2025)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
151,013 individuals (100%)
Score Development/Training
European: 100%
5,540 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST90002238
Europe PMC: 34059833
 151,013 individuals European
(European (Croatia, Denmark, Finland, France, Germany, Greece, Iceland, Italy, Netherlands, Republic of Ireland, Spain, Sweden, Switzerland, U.K., U.S., Australia))		 MAGIC
Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
GWAS Catalog: GCST90245986
Europe PMC: 35902682
 5,540 individuals European TOPMed — — — — —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM022760 PSS012072|
European Ancestry|
13,712 individuals
 PGP000750 |
Sarnowski C et al. Commun Biol (2025)
 Reported Trait: Homeostasis Model Assessment for Insulin Resistance [HOMA-IR] β: 0.237 — R²: 0.1076 age, sex, study, BMI, and the first 11 genetic principal components Score was standardized

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012072 — — 13,712 individuals — European — TOPMed —