PGS Publication: PGP000750

Publication Information (EuropePMC)
Title Association of genetic scores related to insulin resistance with neurological outcomes in ancestrally diverse cohorts from the Trans-Omics for Precision Medicine (TOPMed) program.
PubMed ID 40993182(Europe PMC)
doi 10.1038/s42003-025-08674-9
Publication Date Sept. 24, 2025
Journal Commun Biol
Author(s) Sarnowski C, Zhang Y, Ammous F, Shade LMP, DiCorpo D, Jian X, Arnett DK, Austin TR, Beiser A, Bis JC, Blangero J, Boerwinkle E, Bressler J, Curran JE, DeCarli CS, Doddapaneni H, Dupuis J, Fardo DW, Florez JC, Gabriel S, Gibbs RA, Glahn DC, Gupta N, González HM, González KA, Hatzikotoulas K, Hayden KM, Heckbert SR, Hidalgo B, Huerta-Chagoya A, Hughes TM, Kardia SLR, Kooperberg CL, Launer LJ, Longstreth WT, T2DGGI consortium, MAGIC consortium, Mandla R, Mathias RA, Morris AP, Mosley TH, Nasrallah IM, Nyquist P, Psaty BM, Qi Q, Raffield LM, Rayner NW, Reiner AP, Satizabal CL, Selvin E, Sevilla-Gonzalez MDR, Smith AV, Smith JA, Smith K, Snively BM, Southam L, Sofer T, Suzuki K, Taylor HJ, Udler MS, Viaud-Martinez KA, Wassertheil-Smoller S, Wood AC, Yanek LR, Yin X, Manning AK, Rotter JI, Rich SS, Meigs JB, Fornage M, Seshadri S, Morrison AC, TOPMed Diabetes working group, and the TOPMed Neurocognitive working group.
Released in PGS Catalog: Nov. 10, 2025

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS005276
(FI_PS_EUR)
 PGP000750 |
Sarnowski C et al. Commun Biol (2025)
 Fasting insulin adjusted for BMI BMI-adjusted fasting blood insulin measurement 1,116,555
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005276/ScoringFiles/PGS005276.txt.gz
PGS005277
(FI_PS_AFR)
 PGP000750 |
Sarnowski C et al. Commun Biol (2025)
 Fasting insulin adjusted for BMI BMI-adjusted fasting blood insulin measurement 1,233,791
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005277/ScoringFiles/PGS005277.txt.gz
PGS005278
(FI_PS_AMR)
 PGP000750 |
Sarnowski C et al. Commun Biol (2025)
 Fasting insulin adjusted for BMI BMI-adjusted fasting blood insulin measurement 1,182,208
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005278/ScoringFiles/PGS005278.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM022760 PGS005276
(FI_PS_EUR)
 PSS012072|
European Ancestry|
13,712 individuals
 PGP000750 |
Sarnowski C et al. Commun Biol (2025)
 Reported Trait: Homeostasis Model Assessment for Insulin Resistance [HOMA-IR] β: 0.237 — R²: 0.1076 age, sex, study, BMI, and the first 11 genetic principal components Score was standardized
PPM022761 PGS005277
(FI_PS_AFR)
 PSS012073|
African Ancestry|
4,695 individuals
 PGP000750 |
Sarnowski C et al. Commun Biol (2025)
 Reported Trait: Homeostasis Model Assessment for Insulin Resistance [HOMA-IR] β: 0.129 — R²: 0.0172 age, sex, study, BMI, and the first 11 genetic principal components Score was standardized
PPM022762 PGS005278
(FI_PS_AMR)
 PSS012074|
Hispanic or Latin American Ancestry|
1,693 individuals
 PGP000750 |
Sarnowski C et al. Commun Biol (2025)
 Reported Trait: Homeostasis Model Assessment for Insulin Resistance [HOMA-IR] β: 0.033 — R²: 0.0028 age, sex, study, BMI, and the first 11 genetic principal components Score was standardized

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012073 — — 4,695 individuals — African American or Afro-Caribbean — TOPMed —
PSS012074 — — 1,693 individuals — Hispanic or Latin American — TOPMed —
PSS012072 — — 13,712 individuals — European — TOPMed —