Polygenic Score (PGS) ID: PGS005278

Predicted Trait
Reported Trait Fasting insulin adjusted for BMI
Mapped Trait(s) BMI-adjusted fasting blood insulin measurement (EFO_0008037)
Released in PGS Catalog: Nov. 10, 2025
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Score Details

Score Construction
PGS Name FI_PS_AMR
Development Method
Name PRS-CSx
Parameters UK Biobank AMR reference panel (ldblk_ukbb_amr), phi parameter equal to 1
Variants
Original Genome Build GRCh37
Number of Variants 1,182,208
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000750
Citation (link to publication) Sarnowski C et al. Commun Biol (2025)
Ancestry Distribution
Source of Variant
Associations (GWAS)
Hispanic or Latin American: 100%
16,386 individuals (100%)
Score Development/Training
Hispanic or Latin American: 100%
6,322 individuals (100%)
PGS Evaluation
Hispanic or Latin American: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST90002239
Europe PMC: 34059833
 16,386 individuals Hispanic or Latin American
(Hispanic or Latin American (Mexico, U.S.))		 MAGIC
Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
GWAS Catalog: GCST90245986
Europe PMC: 35902682
 6,322 individuals Hispanic or Latin American TOPMed — — — — —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM022762 PSS012074|
Hispanic or Latin American Ancestry|
1,693 individuals
 PGP000750 |
Sarnowski C et al. Commun Biol (2025)
 Reported Trait: Homeostasis Model Assessment for Insulin Resistance [HOMA-IR] β: 0.033 — R²: 0.0028 age, sex, study, BMI, and the first 11 genetic principal components Score was standardized

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012074 — — 1,693 individuals — Hispanic or Latin American — TOPMed —