Polygenic Score (PGS) ID: PGS005395

Predicted Trait
Reported Trait Prostate carcinoma
Mapped Trait(s) prostate carcinoma (MONDO_0005159)
Released in PGS Catalog: July 15, 2026
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Score Details

Score Construction
PGS Name AFR_PCa_PRS_CSx
Development Method
Name PRS-CSx
Parameters Trained using PRS-CSx (single-population mode) with African ancestry LD reference (1000 Genomes). Parameters: a=1, b=0.5, phi=auto.
Variants
Original Genome Build GRCh37
Number of Variants 138,272
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000779
Citation (link to publication) David E et al. medRxiv (2026) Preprint
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 71.6%
African: 18%
Hispanic or Latin American: 9.3%
East Asian: 1.1%
573,692 individuals (100%)
PGS Evaluation
African: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST90479803
Europe PMC: 39024449
 103,424 individuals African American or Afro-Caribbean MVP
GWAS Catalog: GCST90479803
Europe PMC: 39024449
 53,167 individuals Hispanic or Latin American MVP
GWAS Catalog: GCST90479803
Europe PMC: 39024449
 6,059 individuals East Asian MVP
GWAS Catalog: GCST90479803
Europe PMC: 39024449
 411,042 individuals European MVP

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM023438 PSS012184|
African Ancestry|
2,511 individuals
 PGP000779 |
David E et al. medRxiv (2026)
|Pre		 Reported Trait: Prostate carcinoma OR: 1.4 AUROC: 0.89 Nagelkerke Delta R2: 0.0131 age, sex OR per Standard Deviation

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012184 ICD-10 codes for malignant neoplasm of prostate —
[
  • 250 cases
  • , 2,261 controls
]
 — Sub-Saharan African
(African/African-admixed)		 — UKB —