PGS Preprint: PGP000779

Publication Information (EuropePMC)
Title Deciphering the Genomic Architecture of Three Major Cancers in African-Ancestry Populations
doi 10.64898/2025.12.19.25342629
Publication Date Jan. 24, 2026
Journal medRxiv Preprint
Author(s) David E, Idedia AM, Ekenwaneze CC, Dania OE, Ogunlana OO
Released in PGS Catalog: July 15, 2026

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS005395
(AFR_PCa_PRS_CSx)
 PGP000779 |
David E et al. medRxiv (2026)
|Pre		 Prostate carcinoma prostate carcinoma 138,272
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005395/ScoringFiles/PGS005395.txt.gz
PGS005396
(AFR_BCa_PRS_CSx)
 PGP000779 |
David E et al. medRxiv (2026)
|Pre		 Breast carcinoma breast carcinoma 139,306
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005396/ScoringFiles/PGS005396.txt.gz
PGS005394
(AFR_CRC_PRS_CSx)
 PGP000779 |
David E et al. medRxiv (2026)
|Pre		 Colorectal carcinoma colorectal carcinoma 139,710
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005394/ScoringFiles/PGS005394.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM023438 PGS005395
(AFR_PCa_PRS_CSx)
 PSS012184|
African Ancestry|
2,511 individuals
 PGP000779 |
David E et al. medRxiv (2026)
|Pre		 Reported Trait: Prostate carcinoma OR: 1.4 AUROC: 0.89 Nagelkerke Delta R2: 0.0131 age, sex OR per Standard Deviation
PPM023439 PGS005396
(AFR_BCa_PRS_CSx)
 PSS012182|
African Ancestry|
1,565 individuals
 PGP000779 |
David E et al. medRxiv (2026)
|Pre		 Reported Trait: Breast carcinoma OR: 1.11 AUROC: 0.77 Nagelkerke Delta R2: 0.0018 age, sex OR per Standard Deviation
PPM023437 PGS005394
(AFR_CRC_PRS_CSx)
 PSS012183|
African Ancestry|
1,101 individuals
 PGP000779 |
David E et al. medRxiv (2026)
|Pre		 Reported Trait: Colorectal carcinoma OR: 1.19 AUROC: 0.63 Nagelkerke Delta R2: 0.0051 age, sex OR per Standard Deviation

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012184 ICD-10 codes for malignant neoplasm of prostate —
[
  • 250 cases
  • , 2,261 controls
]
 — Sub-Saharan African
(African/African-admixed)		 — UKB —
PSS012182 ICD-10 codes for malignant neoplasm of breast —
[
  • 166 cases
  • , 1,399 controls
]
 — Sub-Saharan African
(African/African-admixed)		 — UKB —
PSS012183 ICD-10 codes for malignant neoplasm of colon, rectosigmoid junction, and rectum —
[
  • 112 cases
  • , 989 controls
]
 — Sub-Saharan African
(African/African-admixed)		 — UKB —