Polygenic Score (PGS) ID: PGS012555

Predicted Trait
Reported Trait Type 1 diabetes (T1D)
Mapped Trait(s) type 1 diabetes mellitus (MONDO_0005147)
Released in PGS Catalog: May 7, 2026
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Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name TA-PS
Development Method
Name PRS-CSx
Parameters Phi metric (PRS-CSx)
Variants
Original Genome Build GRCh37
Number of Variants 1,116,345
Number of Variant Interaction Terms 14
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000798
Citation (link to publication) Jumentier B et al. Diabetologia (2026)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 62.8%
East Asian: 16.1%
African: 14.1%
Hispanic or Latin American: 7%
828,320 individuals (100%)
Score Development/Training
European: 88.1%
Hispanic or Latin American: 5.1%
African: 3%
South Asian: 2.7%
East Asian: 1.2%
4,657 individuals (100%)
PGS Evaluation
European: 30%
African: 20%
Hispanic or Latin American: 10%
East Asian: 10%
Multi-ancestry (including European): 10%
  • African
  • Hispanic or Latin American
  • European
Additional Diverse Ancestries: 10%
South Asian: 10%
10 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST90014023
Europe PMC: 34012112
 520,580 individuals European NR
GWAS Catalog: GCST90018705
Europe PMC: 34594039
 133,251 individuals East Asian BBJ
GWAS Catalog: GCST90432065
Europe PMC: 38453145
 308 individuals Hispanic or Latin American T1DGC
GWAS Catalog: GCST90432064
Europe PMC: 38453145
 891 individuals African American or Afro-Caribbean T1DGC
GWAS Catalog: GCST90475660
Europe PMC: 39024449
 115,861 individuals African American or Afro-Caribbean MVP
GWAS Catalog: GCST90475659
Europe PMC: 39024449
 57,429 individuals Hispanic or Latin American MVP
Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
—
[
  • 48 cases
  • , 91 controls
]
 African American or Afro-Caribbean MCH_montreal — — — — —
—
[
  • 105 cases
  • , 131 controls
]
 Hispanic or Latin American MCH_montreal — — — — —
—
[
  • 23 cases
  • , 33 controls
]
 East Asian MCH_montreal — — — — —
—
[
  • 2,193 cases
  • , 1,908 controls
]
 European MCH_montreal — — — — —
—
[
  • 47 cases
  • , 78 controls
]
 South Asian MCH_montreal — — — — —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM030675 PSS012239|
African Ancestry|
1,687 individuals
 PGP000798 |
Jumentier B et al. Diabetologia (2026)
 Reported Trait: type 1 diabetes — AUROC: 0.729 [0.699, 0.759] — — sensitivity (%, cutoff of 10) = 0.310, specificity (%, cutoff of 10) = 0.941, F1 score = 0.409
PPM030676 PSS012240|
European Ancestry|
2,828 individuals
 PGP000798 |
Jumentier B et al. Diabetologia (2026)
 Reported Trait: type 1 diabetes — AUROC: 0.777 [0.754, 0.8] — — sensitivity (%, cutoff of 10) = 0.409, specificity (%, cutoff of 10) = 0.900, F1 score = 0.428
PPM030677 PSS012242|
South Asian Ancestry|
315 individuals
 PGP000798 |
Jumentier B et al. Diabetologia (2026)
 Reported Trait: type 1 diabetes — AUROC: 0.736 [0.644, 0.829] — — sensitivity (%, cutoff of 10) = 0.333, specificity (%, cutoff of 10) = 0.883, F1 score = 0.270
PPM030678 PSS012241|
Additional Diverse Ancestries|
1,285 individuals
 PGP000798 |
Jumentier B et al. Diabetologia (2026)
 Reported Trait: type 1 diabetes — AUROC: 0.72 [0.678, 0.762] — — sensitivity (%, cutoff of 10) = 0.366, specificity (%, cutoff of 10) = 0.913, F1 score = 0.399
PPM030679 PSS012243|
East Asian Ancestry|
596 individuals
 PGP000798 |
Jumentier B et al. Diabetologia (2026)
 Reported Trait: type 1 diabetes — AUROC: 0.81 [0.775, 0.844] — — sensitivity (%, cutoff of 10) = 0.527, specificity (%, cutoff of 10) = 0.897, F1 score = 0.646
PPM030681 PSS012237|
Hispanic or Latin American Ancestry|
18,753 individuals
 PGP000798 |
Jumentier B et al. Diabetologia (2026)
 Reported Trait: type 1 diabetes — AUROC: 0.688 [0.654, 0.688] — — sensitivity (%, cutoff of 10) = 0.329, specificity (%, cutoff of 10) = 0.903, F1 score = 0.069
PPM030682 PSS012235|
African Ancestry|
14,974 individuals
 PGP000798 |
Jumentier B et al. Diabetologia (2026)
 Reported Trait: type 1 diabetes — AUROC: 0.652 [0.61, 0.652] — — sensitivity (%, cutoff of 10) = 0.335, specificity (%, cutoff of 10) = 0.903, F1 score = 0.080
PPM030683 PSS012238|
Multi-ancestry (including European)|
86,010 individuals
 PGP000798 |
Jumentier B et al. Diabetologia (2026)
 Reported Trait: type 1 diabetes — AUROC: 0.752 [0.735, 0.769] — — sensitivity (%, cutoff of 10) = 0.460, specificity (%, cutoff of 10) = 0.904, F1 score = 0.096
PPM030684 PSS012244|
European Ancestry|
406,390 individuals
 PGP000798 |
Jumentier B et al. Diabetologia (2026)
 Reported Trait: type 1 diabetes — AUROC: 0.857 [0.842, 0.873] — — sensitivity (%, cutoff of 10) = 0.669, specificity (%, cutoff of 10) = 0.900, F1 score = 0.024
PPM030680 PSS012236|
European Ancestry|
52,283 individuals
 PGP000798 |
Jumentier B et al. Diabetologia (2026)
 Reported Trait: type 1 diabetes — AUROC: 0.821 [0.8, 0.821] — — sensitivity (%, cutoff of 10) = 0.597, specificity (%, cutoff of 10) = 0.905, F1 score = 0.116

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012235 — —
[
  • 201 cases
  • , 14,773 controls
]
 — African American or Afro-Caribbean — AllofUs —
PSS012236 — —
[
  • 584 cases
  • , 51,699 controls
]
 — European — AllofUs —
PSS012237 — —
[
  • 261 cases
  • , 18,492 controls
]
 — Hispanic or Latin American — AllofUs —
PSS012238 — —
[
  • 201 cases
  • , 14,773 controls
]
 — African American or Afro-Caribbean — AllofUs —
PSS012238 — —
[
  • 261 cases
  • , 18,492 controls
]
 — Hispanic or Latin American — AllofUs —
PSS012238 — —
[
  • 584 cases
  • , 51,699 controls
]
 — European — AllofUs —
PSS012239 — —
[
  • 371 cases
  • , 1,316 controls
]
 — African American or Afro-Caribbean — CHOP —
PSS012240 — —
[
  • 474 cases
  • , 2,354 controls
]
 — European — CHOP —
PSS012241 — —
[
  • 202 cases
  • , 1,083 controls
]
 — Other admixed ancestry — CHOP —
PSS012242 — —
[
  • 30 cases
  • , 285 controls
]
 — South Asian — CHOP —
PSS012243 — —
[
  • 293 cases
  • , 303 controls
]
 — East Asian — GRACE —
PSS012244 — —
[
  • 733 cases
  • , 405,657 controls
]
 — European — UKB —