PGS Publication: PGP000798

Publication Information (EuropePMC)
Title Development and validation of a trans-ancestry polygenic risk score for type 1 diabetes.
PubMed ID 41795035(Europe PMC)
doi 10.1007/s00125-026-06706-5
Publication Date March 7, 2026
Journal Diabetologia
Author(s) Jumentier B, Qu HQ, Lu T, Liu K, Kleinbrink EL, Klein K, Belbellaj W, Gamache I, Ferrat L, Butler-Laporte G, Li Y, Hakonarson H, Wu W, Polychronakos C, Greenwood CMT, Manousaki D.
Released in PGS Catalog: May 7, 2026

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS012555
(TA-PS)
 PGP000798 |
Jumentier B et al. Diabetologia (2026)
 Type 1 diabetes (T1D) type 1 diabetes mellitus 1,116,345
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS012555/ScoringFiles/PGS012555.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM030675 PGS012555
(TA-PS)
 PSS012239|
African Ancestry|
1,687 individuals
 PGP000798 |
Jumentier B et al. Diabetologia (2026)
 Reported Trait: type 1 diabetes — AUROC: 0.729 [0.699, 0.759] — — sensitivity (%, cutoff of 10) = 0.310, specificity (%, cutoff of 10) = 0.941, F1 score = 0.409
PPM030676 PGS012555
(TA-PS)
 PSS012240|
European Ancestry|
2,828 individuals
 PGP000798 |
Jumentier B et al. Diabetologia (2026)
 Reported Trait: type 1 diabetes — AUROC: 0.777 [0.754, 0.8] — — sensitivity (%, cutoff of 10) = 0.409, specificity (%, cutoff of 10) = 0.900, F1 score = 0.428
PPM030677 PGS012555
(TA-PS)
 PSS012242|
South Asian Ancestry|
315 individuals
 PGP000798 |
Jumentier B et al. Diabetologia (2026)
 Reported Trait: type 1 diabetes — AUROC: 0.736 [0.644, 0.829] — — sensitivity (%, cutoff of 10) = 0.333, specificity (%, cutoff of 10) = 0.883, F1 score = 0.270
PPM030678 PGS012555
(TA-PS)
 PSS012241|
Additional Diverse Ancestries|
1,285 individuals
 PGP000798 |
Jumentier B et al. Diabetologia (2026)
 Reported Trait: type 1 diabetes — AUROC: 0.72 [0.678, 0.762] — — sensitivity (%, cutoff of 10) = 0.366, specificity (%, cutoff of 10) = 0.913, F1 score = 0.399
PPM030679 PGS012555
(TA-PS)
 PSS012243|
East Asian Ancestry|
596 individuals
 PGP000798 |
Jumentier B et al. Diabetologia (2026)
 Reported Trait: type 1 diabetes — AUROC: 0.81 [0.775, 0.844] — — sensitivity (%, cutoff of 10) = 0.527, specificity (%, cutoff of 10) = 0.897, F1 score = 0.646
PPM030681 PGS012555
(TA-PS)
 PSS012237|
Hispanic or Latin American Ancestry|
18,753 individuals
 PGP000798 |
Jumentier B et al. Diabetologia (2026)
 Reported Trait: type 1 diabetes — AUROC: 0.688 [0.654, 0.688] — — sensitivity (%, cutoff of 10) = 0.329, specificity (%, cutoff of 10) = 0.903, F1 score = 0.069
PPM030682 PGS012555
(TA-PS)
 PSS012235|
African Ancestry|
14,974 individuals
 PGP000798 |
Jumentier B et al. Diabetologia (2026)
 Reported Trait: type 1 diabetes — AUROC: 0.652 [0.61, 0.652] — — sensitivity (%, cutoff of 10) = 0.335, specificity (%, cutoff of 10) = 0.903, F1 score = 0.080
PPM030683 PGS012555
(TA-PS)
 PSS012238|
Multi-ancestry (including European)|
86,010 individuals
 PGP000798 |
Jumentier B et al. Diabetologia (2026)
 Reported Trait: type 1 diabetes — AUROC: 0.752 [0.735, 0.769] — — sensitivity (%, cutoff of 10) = 0.460, specificity (%, cutoff of 10) = 0.904, F1 score = 0.096
PPM030684 PGS012555
(TA-PS)
 PSS012244|
European Ancestry|
406,390 individuals
 PGP000798 |
Jumentier B et al. Diabetologia (2026)
 Reported Trait: type 1 diabetes — AUROC: 0.857 [0.842, 0.873] — — sensitivity (%, cutoff of 10) = 0.669, specificity (%, cutoff of 10) = 0.900, F1 score = 0.024
PPM030680 PGS012555
(TA-PS)
 PSS012236|
European Ancestry|
52,283 individuals
 PGP000798 |
Jumentier B et al. Diabetologia (2026)
 Reported Trait: type 1 diabetes — AUROC: 0.821 [0.8, 0.821] — — sensitivity (%, cutoff of 10) = 0.597, specificity (%, cutoff of 10) = 0.905, F1 score = 0.116

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012235 — —
[
  • 201 cases
  • , 14,773 controls
]
 — African American or Afro-Caribbean — AllofUs —
PSS012236 — —
[
  • 584 cases
  • , 51,699 controls
]
 — European — AllofUs —
PSS012237 — —
[
  • 261 cases
  • , 18,492 controls
]
 — Hispanic or Latin American — AllofUs —
PSS012238 — —
[
  • 201 cases
  • , 14,773 controls
]
 — African American or Afro-Caribbean — AllofUs —
PSS012238 — —
[
  • 261 cases
  • , 18,492 controls
]
 — Hispanic or Latin American — AllofUs —
PSS012238 — —
[
  • 584 cases
  • , 51,699 controls
]
 — European — AllofUs —
PSS012239 — —
[
  • 371 cases
  • , 1,316 controls
]
 — African American or Afro-Caribbean — CHOP —
PSS012240 — —
[
  • 474 cases
  • , 2,354 controls
]
 — European — CHOP —
PSS012241 — —
[
  • 202 cases
  • , 1,083 controls
]
 — Other admixed ancestry — CHOP —
PSS012242 — —
[
  • 30 cases
  • , 285 controls
]
 — South Asian — CHOP —
PSS012243 — —
[
  • 293 cases
  • , 303 controls
]
 — East Asian — GRACE —
PSS012244 — —
[
  • 733 cases
  • , 405,657 controls
]
 — European — UKB —