Polygenic Score (PGS) ID: PGS012562

Predicted Trait
Reported Trait Peptic ulcer disease
Mapped Trait(s) peptic ulcer disease (MONDO_0004247)
Released in PGS Catalog: May 7, 2026
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Score Details

Score Construction
PGS Name PRS8_PU
Development Method
Name Genome-wide significant SNPs
Parameters p<5E-08
Variants
Original Genome Build NR
Number of Variants 8
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000802
Citation (link to publication) Li J et al. Environ Res (2024)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
456,327 individuals (100%)
PGS Evaluation
European: 100%
2 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST011504
Europe PMC: 33608531
 456,327 individuals European NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM030694 PSS012252|
European Ancestry|
244,369 individuals
 PGP000802 |
Li J et al. Environ Res (2024)
 Reported Trait: Incident peptic ulcer HR: 2.136 [1.724, 2.646] — — age, sex, household income, education, BMI, smoking status, alcohol drinking status, physical activity, and healthy diet pattern —
PPM030696 PSS012252|
European Ancestry|
244,369 individuals
 PGP000802 |
Li J et al. Environ Res (2024)
 Reported Trait: Incident peptic ulcer x ambient air pollutant NO2 interaction — — Hazard ratio (HR, high pollution and high PRS vs. low pollution and low PRS): 1.762 [1.395, 2.227] age, sex, household income, education, BMI, smoking status, alcohol drinking status, physical activity, and healthy diet pattern —
PPM030693 PSS012253|
European Ancestry|
226,053 individuals
 PGP000802 |
Li J et al. Environ Res (2024)
 Reported Trait: Incident peptic ulcer HR: 2.171 [1.744, 2.703] — — age, sex, household income, education, BMI, smoking status, alcohol drinking status, physical activity, and healthy diet pattern —
PPM030695 PSS012253|
European Ancestry|
226,053 individuals
 PGP000802 |
Li J et al. Environ Res (2024)
 Reported Trait: Incident peptic ulcer x ambient air pollutant PM2.5 interaction — — Hazard ratio (HR, high pollution and high PRS vs. low pollution and low PRS): 1.558 [1.384, 1.754] age, sex, household income, education, BMI, smoking status, alcohol drinking status, physical activity, and healthy diet pattern —
PPM030697 PSS012252|
European Ancestry|
244,369 individuals
 PGP000802 |
Li J et al. Environ Res (2024)
 Reported Trait: Incident peptic ulcer x ambient air pollutant NOx interaction — — Hazard ratio (HR, high pollution and high PRS vs. low pollution and low PRS): 1.575 [1.403, 1.769] age, sex, household income, education, BMI, smoking status, alcohol drinking status, physical activity, and healthy diet pattern —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012252 — — 244,369 individuals — European — UKB —
PSS012253 — — 226,053 individuals — European — UKB —