PGS Publication: PGP000802

Publication Information (EuropePMC)
Title Air pollutants, genetic susceptibility, and the risk of incident gastrointestinal diseases: A large prospective cohort study.
PubMed ID 38218525(Europe PMC)
doi 10.1016/j.envres.2024.118182
Publication Date Jan. 11, 2024
Journal Environ Res
Author(s) Li J, He C, Ying J, Hua B, Yang Y, Chen W, Liu W, Ye D, Sun X, Mao Y, Chen K.
Released in PGS Catalog: May 7, 2026

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS012562
(PRS8_PU)
 PGP000802 |
Li J et al. Environ Res (2024)
 Peptic ulcer disease peptic ulcer disease 8
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS012562/ScoringFiles/PGS012562.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM030694 PGS012562
(PRS8_PU)
 PSS012252|
European Ancestry|
244,369 individuals
 PGP000802 |
Li J et al. Environ Res (2024)
 Reported Trait: Incident peptic ulcer HR: 2.136 [1.724, 2.646] — — age, sex, household income, education, BMI, smoking status, alcohol drinking status, physical activity, and healthy diet pattern —
PPM030696 PGS012562
(PRS8_PU)
 PSS012252|
European Ancestry|
244,369 individuals
 PGP000802 |
Li J et al. Environ Res (2024)
 Reported Trait: Incident peptic ulcer x ambient air pollutant NO2 interaction — — Hazard ratio (HR, high pollution and high PRS vs. low pollution and low PRS): 1.762 [1.395, 2.227] age, sex, household income, education, BMI, smoking status, alcohol drinking status, physical activity, and healthy diet pattern —
PPM030693 PGS012562
(PRS8_PU)
 PSS012253|
European Ancestry|
226,053 individuals
 PGP000802 |
Li J et al. Environ Res (2024)
 Reported Trait: Incident peptic ulcer HR: 2.171 [1.744, 2.703] — — age, sex, household income, education, BMI, smoking status, alcohol drinking status, physical activity, and healthy diet pattern —
PPM030695 PGS012562
(PRS8_PU)
 PSS012253|
European Ancestry|
226,053 individuals
 PGP000802 |
Li J et al. Environ Res (2024)
 Reported Trait: Incident peptic ulcer x ambient air pollutant PM2.5 interaction — — Hazard ratio (HR, high pollution and high PRS vs. low pollution and low PRS): 1.558 [1.384, 1.754] age, sex, household income, education, BMI, smoking status, alcohol drinking status, physical activity, and healthy diet pattern —
PPM030697 PGS012562
(PRS8_PU)
 PSS012252|
European Ancestry|
244,369 individuals
 PGP000802 |
Li J et al. Environ Res (2024)
 Reported Trait: Incident peptic ulcer x ambient air pollutant NOx interaction — — Hazard ratio (HR, high pollution and high PRS vs. low pollution and low PRS): 1.575 [1.403, 1.769] age, sex, household income, education, BMI, smoking status, alcohol drinking status, physical activity, and healthy diet pattern —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012252 — — 244,369 individuals — European — UKB —
PSS012253 — — 226,053 individuals — European — UKB —