Polygenic Score (PGS) ID: PGS012563

Predicted Trait
Reported Trait Abdominal aortic aneurysm
Mapped Trait(s) abdominal aortic aneurysm (MONDO_0005350)
Released in PGS Catalog: May 7, 2026
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Score Details

Score Construction
PGS Name PRS31_AAA
Development Method
Name Genome-wide Significant SNPs
Parameters r2 < 0.05, minor allele frequency >0.05 and P < 1E-05
Variants
Original Genome Build NR
Number of Variants 31
Effect Weight Type log(OR)
PGS Source
PGS Catalog Publication (PGP) ID PGP000803
Citation (link to publication) Ma Y et al. Eur Heart J (2024)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
284,644 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST003877
Europe PMC: 27899403
 104,830 individuals European NR
GWAS Catalog: GCST011496
Europe PMC: 32981348
 179,814 individuals European NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM030698 PSS012254|
European Ancestry|
449,463 individuals
 PGP000803 |
Ma Y et al. Eur Heart J (2024)
 Reported Trait: Incident Abdominal aortic aneurysm HR: 1.25 [1.19, 1.31] — — age, sex, family income, TDI, education, employment, alcohol consumption status, tobacco consumption status, healthy diet score, physical activity, BMI, eGFR, SBP, HbA1c, lipid profile, anti-hypertensive medication, anti-hyperglycemic medication, lipid-lowering medication, genotyping batch, and the first 10 genetic principal components —
PPM030699 PSS012254|
European Ancestry|
449,463 individuals
 PGP000803 |
Ma Y et al. Eur Heart J (2024)
 Reported Trait: Incident Abdominal aortic aneurysm x PM2.5 pollution exposure interaction — — Hazard ratio (HR, high air pollutants exposure and high PRS vs. low air pollutants exposure and low PRS): 3.18 [2.46, 4.12] age, sex, family income, Townsend deprivation index, education, employment, alcohol consumption status, tobacco consumption status, healthy diet score, physical activity, body mass index, estimated glomerular filtration rate, systolic blood pressure, glycated haemoglobin, lipid profile, anti-hypertensive medication, anti-hyperglycaemic medication, and lipid-lowering medication, genotyping batch, the first 10 genetic principal components —
PPM030700 PSS012254|
European Ancestry|
449,463 individuals
 PGP000803 |
Ma Y et al. Eur Heart J (2024)
 Reported Trait: Incident Abdominal aortic aneurysm x PM10 pollution exposure interaction — — Hazard ratio (HR, high air pollutants exposure and high PRS vs. low air pollutants exposure and low PRS): 3.09 [2.39, 4.0] age, sex, family income, Townsend deprivation index, education, employment, alcohol consumption status, tobacco consumption status, healthy diet score, physical activity, body mass index, estimated glomerular filtration rate, systolic blood pressure, glycated haemoglobin, lipid profile, anti-hypertensive medication, anti-hyperglycaemic medication, and lipid-lowering medication, genotyping batch, the first 10 genetic principal components —
PPM030701 PSS012254|
European Ancestry|
449,463 individuals
 PGP000803 |
Ma Y et al. Eur Heart J (2024)
 Reported Trait: Incident Abdominal aortic aneurysm x NO2 pollution exposure interaction — — Hazard ratio (HR, high air pollutants exposure and high PRS vs. low air pollutants exposure and low PRS): 2.41 [1.86, 3.13] age, sex, family income, Townsend deprivation index, education, employment, alcohol consumption status, tobacco consumption status, healthy diet score, physical activity, body mass index, estimated glomerular filtration rate, systolic blood pressure, glycated haemoglobin, lipid profile, anti-hypertensive medication, anti-hyperglycaemic medication, and lipid-lowering medication, genotyping batch, the first 10 genetic principal components —
PPM030702 PSS012254|
European Ancestry|
449,463 individuals
 PGP000803 |
Ma Y et al. Eur Heart J (2024)
 Reported Trait: Incident Abdominal aortic aneurysm x NOx pollution exposure interaction — — Hazard ratio (HR, high air pollutants exposure and high PRS vs. low air pollutants exposure and low PRS): 2.01 [1.55, 2.61] age, sex, family income, Townsend deprivation index, education, employment, alcohol consumption status, tobacco consumption status, healthy diet score, physical activity, body mass index, estimated glomerular filtration rate, systolic blood pressure, glycated haemoglobin, lipid profile, anti-hypertensive medication, anti-hyperglycaemic medication, and lipid-lowering medication, genotyping batch, the first 10 genetic principal components —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012254 — Median = 12.66 years
[
  • 1,626 cases
  • , 447,837 controls
]
,
44.39 % Male samples
 Mean = 56.22 years
Sd = 8.09 years		 European — UKB —