PGS Publication: PGP000803

Publication Information (EuropePMC)
Title Air pollutants, genetic susceptibility, and abdominal aortic aneurysm risk: a prospective study.
PubMed ID 38241289(Europe PMC)
doi 10.1093/eurheartj/ehad886
Publication Date March 1, 2024
Journal Eur Heart J
Author(s) Ma Y, Li D, Cui F, Wang J, Tang L, Yang Y, Liu R, Tian Y.
Released in PGS Catalog: May 7, 2026

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS012563
(PRS31_AAA)
 PGP000803 |
Ma Y et al. Eur Heart J (2024)
 Abdominal aortic aneurysm abdominal aortic aneurysm 31
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS012563/ScoringFiles/PGS012563.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM030698 PGS012563
(PRS31_AAA)
 PSS012254|
European Ancestry|
449,463 individuals
 PGP000803 |
Ma Y et al. Eur Heart J (2024)
 Reported Trait: Incident Abdominal aortic aneurysm HR: 1.25 [1.19, 1.31] — — age, sex, family income, TDI, education, employment, alcohol consumption status, tobacco consumption status, healthy diet score, physical activity, BMI, eGFR, SBP, HbA1c, lipid profile, anti-hypertensive medication, anti-hyperglycemic medication, lipid-lowering medication, genotyping batch, and the first 10 genetic principal components —
PPM030699 PGS012563
(PRS31_AAA)
 PSS012254|
European Ancestry|
449,463 individuals
 PGP000803 |
Ma Y et al. Eur Heart J (2024)
 Reported Trait: Incident Abdominal aortic aneurysm x PM2.5 pollution exposure interaction — — Hazard ratio (HR, high air pollutants exposure and high PRS vs. low air pollutants exposure and low PRS): 3.18 [2.46, 4.12] age, sex, family income, Townsend deprivation index, education, employment, alcohol consumption status, tobacco consumption status, healthy diet score, physical activity, body mass index, estimated glomerular filtration rate, systolic blood pressure, glycated haemoglobin, lipid profile, anti-hypertensive medication, anti-hyperglycaemic medication, and lipid-lowering medication, genotyping batch, the first 10 genetic principal components —
PPM030700 PGS012563
(PRS31_AAA)
 PSS012254|
European Ancestry|
449,463 individuals
 PGP000803 |
Ma Y et al. Eur Heart J (2024)
 Reported Trait: Incident Abdominal aortic aneurysm x PM10 pollution exposure interaction — — Hazard ratio (HR, high air pollutants exposure and high PRS vs. low air pollutants exposure and low PRS): 3.09 [2.39, 4.0] age, sex, family income, Townsend deprivation index, education, employment, alcohol consumption status, tobacco consumption status, healthy diet score, physical activity, body mass index, estimated glomerular filtration rate, systolic blood pressure, glycated haemoglobin, lipid profile, anti-hypertensive medication, anti-hyperglycaemic medication, and lipid-lowering medication, genotyping batch, the first 10 genetic principal components —
PPM030701 PGS012563
(PRS31_AAA)
 PSS012254|
European Ancestry|
449,463 individuals
 PGP000803 |
Ma Y et al. Eur Heart J (2024)
 Reported Trait: Incident Abdominal aortic aneurysm x NO2 pollution exposure interaction — — Hazard ratio (HR, high air pollutants exposure and high PRS vs. low air pollutants exposure and low PRS): 2.41 [1.86, 3.13] age, sex, family income, Townsend deprivation index, education, employment, alcohol consumption status, tobacco consumption status, healthy diet score, physical activity, body mass index, estimated glomerular filtration rate, systolic blood pressure, glycated haemoglobin, lipid profile, anti-hypertensive medication, anti-hyperglycaemic medication, and lipid-lowering medication, genotyping batch, the first 10 genetic principal components —
PPM030702 PGS012563
(PRS31_AAA)
 PSS012254|
European Ancestry|
449,463 individuals
 PGP000803 |
Ma Y et al. Eur Heart J (2024)
 Reported Trait: Incident Abdominal aortic aneurysm x NOx pollution exposure interaction — — Hazard ratio (HR, high air pollutants exposure and high PRS vs. low air pollutants exposure and low PRS): 2.01 [1.55, 2.61] age, sex, family income, Townsend deprivation index, education, employment, alcohol consumption status, tobacco consumption status, healthy diet score, physical activity, body mass index, estimated glomerular filtration rate, systolic blood pressure, glycated haemoglobin, lipid profile, anti-hypertensive medication, anti-hyperglycaemic medication, and lipid-lowering medication, genotyping batch, the first 10 genetic principal components —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012254 — Median = 12.66 years
[
  • 1,626 cases
  • , 447,837 controls
]
,
44.39 % Male samples
 Mean = 56.22 years
Sd = 8.09 years		 European — UKB —