Polygenic Score (PGS) ID: PGS012564

Predicted Trait
Reported Trait Chronic obstructive pulmonary disease
Mapped Trait(s) chronic obstructive pulmonary disease (MONDO_0005002)
Released in PGS Catalog: May 7, 2026
Download Score FTP directory
Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name GRS22_COPD
Development Method
Name genome-wide association SNPs
Parameters NR
Variants
Original Genome Build NR
Number of Variants 22
Effect Weight Type log(OR)
PGS Source
PGS Catalog Publication (PGP) ID PGP000808
Citation (link to publication) Li J et al. BMC Med (2024)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 81.2%
East Asian: 11.8%
African: 6%
Hispanic or Latin American: 1%
58,918 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST004147
Europe PMC: 28166215
 3,522 individuals African American or Afro-Caribbean NR
GWAS Catalog: GCST004147
Europe PMC: 28166215
 600 individuals Hispanic or Latin American NR
GWAS Catalog: GCST004147
Europe PMC: 28166215
 47,856 individuals European NR
GWAS Catalog: GCST004147
Europe PMC: 28166215
 6,940 individuals East Asian NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM030710 PSS012261|
European Ancestry|
277,059 individuals
 PGP000808 |
Li J et al. BMC Med (2024)
 Reported Trait: Incident COPD HR: 1.09 [1.06, 1.12] — — age, sex, and the first 10 principal components of ancestry —
PPM030711 PSS012261|
European Ancestry|
277,059 individuals
 PGP000808 |
Li J et al. BMC Med (2024)
 Reported Trait: Incident COPD x current work schedule interaction — — Hazard ratio (HR, usual/permanent night shift and high PRS vs. day workers and low PRS): 1.9 [1.63, 2.22] age, sex, BMI, Townsend deprivation index, sleep duration, smoking status, alcohol drinking, IPAQ activity group, chronotype, asthma —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012261 — — 277,059 individuals,
48.03 % Male samples
 Mean = 52.71 years
Sd = 7.08 years		 European — UKB —