PGS Publication: PGP000808

Publication Information (EuropePMC)
Title Associations between long-term night shift work and incidence of chronic obstructive pulmonary disease: a prospective cohort study of 277,059 UK Biobank participants.
PubMed ID 38225649(Europe PMC)
doi 10.1186/s12916-023-03240-8
Publication Date Jan. 16, 2024
Journal BMC Med
Author(s) Li J, Yang L, Yao Y, Gu P, Xie Y, Yin H, Xue M, Jiang Y, Dai J, Ma J.
Released in PGS Catalog: May 7, 2026

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS012564
(GRS22_COPD)
 PGP000808 |
Li J et al. BMC Med (2024)
 Chronic obstructive pulmonary disease chronic obstructive pulmonary disease 22
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS012564/ScoringFiles/PGS012564.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM030710 PGS012564
(GRS22_COPD)
 PSS012261|
European Ancestry|
277,059 individuals
 PGP000808 |
Li J et al. BMC Med (2024)
 Reported Trait: Incident COPD HR: 1.09 [1.06, 1.12] — — age, sex, and the first 10 principal components of ancestry —
PPM030711 PGS012564
(GRS22_COPD)
 PSS012261|
European Ancestry|
277,059 individuals
 PGP000808 |
Li J et al. BMC Med (2024)
 Reported Trait: Incident COPD x current work schedule interaction — — Hazard ratio (HR, usual/permanent night shift and high PRS vs. day workers and low PRS): 1.9 [1.63, 2.22] age, sex, BMI, Townsend deprivation index, sleep duration, smoking status, alcohol drinking, IPAQ activity group, chronotype, asthma —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012261 — — 277,059 individuals,
48.03 % Male samples
 Mean = 52.71 years
Sd = 7.08 years		 European — UKB —